Chloroquine lysosomal membrane permeabilization

Discussion in 'Aralen 150 Mg' started by Rokkis, 10-Mar-2020.

  1. xotabhik Guest

    Chloroquine lysosomal membrane permeabilization

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    Sep 25, 2017 Chloroquine triggers lysosomal membrane permeabilization in A549cisR cells, promoting the release of lysosomal cathepsins into the cytosol. To investigate the mechanisms of lysosomal cell death, we characterized the cytotoxic action of two widely used quinolone antibiotics ciprofloxacin CPX or norfloxacin NFX. CPX or NFX plus UV light NFX* induce lysosomal membrane permeabilization LMP, as detected by the release of cathepsins from lysosomes. Chloroquine is a lysosomotropic agent that triggers destabilization of the lysosomal membrane in various tumor cells. In one study chloroquine was used to restore sensitivity to cisplatin in refractory non-small-cell lung cancer cells 82.

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    Chloroquine lysosomal membrane permeabilization

    ASMase regulates autophagy and lysosomal membrane., Lysosomal Membrane Permeabilization Induces Cell Death in.

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  7. Chloroquine induces permeabilization of lysosomal membranes As a lysosomotropic agent, CQ can rapidly diffuse into cells and been trapped in lysosomes. 17 We first labeled lysosomes with LysoTracker red DND-99 and monitored morphological changes of lysosomes associated with CQ treatment.

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    Chloroquine-induced lysosomal membrane permeabilization restores sensitivity to cisplatin in refractory lung cancer cells. abstract. In Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Furthermore, it has been reported that chloroquine causes direct lysosomal membrane permeabilization, with the subsequent release of lysosomal products i.e. cathepsins from the lysosomal lumen into the cytosol. Normal lysosomal degradation function is crucial to maintain cellular homeostasis and enable cell survival in the physiological state. Due to its high hydrolase content, lysosomes are potentially harmful to the cell when damage occurs to the lysosomal membrane to induce lysosomal membrane permeabilization LMP.

  8. BayconUr Moderator

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  9. Krumer New Member

    Hydroxychloroquine retinopathy — implications of research. Hydroxychloroquine is a front-line treatment for systemic lupus erythematosus and other rheumatic diseases, but can cause retinopathy. Improved detection techniques for the early stages pre.

    Hydroxychloroquine retinopathy A review of imaging
  10. Karina New Member

    Chloroquine Phosphate Forums for Fish Lovers! I've been doing some reading on fish parasites and ways to kill the parasite and I came across chloroquine phosphate which seems like something that would useful to have handy. It claims to kill ich, velvet, brooklynella and uronema so if it kills all that why is no recommending it?

    Fish compatibility Forums for Fish Lovers!