One of the most common and beneficial T2DM drugs may contribute to neuropathy and vitamin deficiency The link between metformin and vitamin B12 lowering is well-known and mentioned in American Diabetes Association guidelines as a disadvantage of the drug. However, there are no recommendations for monitoring and prevention of vitamin B12 deficiency for patients taking metformin. Vitamin B12 deficiency is associated with adverse effects such as fatigue, mental status changes, and neuropathy. Given the prevalence of neuropathy in diabetic patients, metformin-induced vitamin B12 deficiency is clinically relevant. The relationship between vitamin B12 deficiency and metformin was studied in a recent randomized placebo-controlled trial. The trial lasted 52 months and included 390 type 2 diabetes patients. They were treated with 850 mg metformin at doses up to three times a day or placebo. While not indicated to treat polycystic ovary syndrome (PCOS), metformin is the most commonly prescribed medication to help women suffering from the condition. Alarming new research is showing a relationship between long-term metformin use and vitamin B12 deficiency, yet most health care providers rarely check B12 status in metformin users. A lack of vitamin B12 can result in serious and permanent neurological and nerve damage. Here’s what to know about vitamin B12 if you take metformin. Metformin works as an insulin-sensitizer to reduce your production of glucose and is commonly prescribed to individuals with type 2 diabetes for this reason. Other names for metformin include glucophage, glucophage XR, glumetza, and fortamet. Metformin lowers blood glucose and insulin levels in several ways: It suppresses the liver's production of glucose, increases the sensitivity of your liver, muscle, fat, and cells to the insulin your body makes, and decreases the absorption of carbohydrates you consume. Amoxicillin side effects in children Prednisone 20 mg gout Cheap nolvadex for sale Researchers say metformin could be reducing vitamin B12 levels in some people with diabetes. Share on Pinterest People with diabetes who take metformin are urged to get their vitamin B12 levels. Mar 16, 2016. Long-term use of the popular diabetes drug metformin is linked with vitamin B12 deficiency and anemia, according to new research that. Metformin and Vitamin B12. By Joseph Gustaitis. The researchers discovered that at the five-year point, the average levels of vitamin B12 in the blood of metformin users were lower than in the blood of the placebo group — 4.3% of the metformin group had low B12 levels, while only 2.3% of Incidence of Type II Diabetes Mellitus (T2DM) is increasing; majority of which is managed in primary care. NICE recommends starting Metformin as a first-line therapy. Studies have linked Metformin use with Vitamin B12 deficiency and suggest that regular monitoring of levels is warranted. Literature suggests that the risk of developing B12 deficiency is greatly influenced by high doses and long duration of therapy. An audit was conducted at Hucknall Road Medical Centre in Nottingham, to determine whether GPs are checking serum B12 level in patients on Metformin. The first phase of the audit concluded that 64% of patients have not had their Vitamin B12 tested. The first phase revealed that 6.4% of the patients were already deficient and on replacement injections while on Metformin. The second phase of the audit determined whether patients would comply if invited to have their Vitamin B12 tested. Joseph Pritchard graduated from Our Lady of Fatima Medical School with a medical degree. View Full Profile How much metformin you take and the duration you take it affect your risk of developing vitamin B-12 deficiency, according to a study published in a 2006 issue of the journal “Archives of Internal Medicine.” The study had 155 participants who suffered from vitamin B-12 deficiency resulting from metformin use. Pritchard writes as a San Francisco biology expert for a prominent website and thoroughly enjoys sharing the knowledge he has accumulated. The results of the study indicated that each 1 g daily of metformin caused a ratio of 2.88 increase in the risk of developing vitamin B-12 deficiency. Patients using metformin for three or more years had a lower ratio of 2.39. This suggests that it is possible to use metformin, by dosage and duration of treatment, as a basis for devising a method of preventing vitamin B-12 deficiency. The results also help determine how much supplementation is needed to maintain healthy levels of the vitamin B-12. Treating vitamin B-12 deficiency generally involves the use of either oral or intramuscular vitamin B-12 supplements, according to the American Family Physician website. Metformin vitamin b12 Metformin Linked to B12 Deficiency, Long-Term Metformin Use Linked with Vitamin B12 Deficiency Lasix furosemideCiprofloxacin eye drops for cats Chronic metformin use results in vitamin B12 deficiency in 30% of patients. Exhaustion of vitamin B12 stores usually occurs after twelve to fifteen years Metformin-induced Vitamin B12 Deficiency Presenting as a.. Metformin and Vitamin B12 - Diabetes Self. Long-Term Metformin Use Linked with Vitamin. Barking, Havering and Redbridge University Hospitals NHS Trust, London, UK; 2 Nottingham University Hospitals NHS Trust, Nottingham, UK. Incidence of. Among those taking metformin, average vitamin B12 levels were lower and 4 percent were deficient compared to 2 percent in the placebo group. 3 Further, nearly 20 percent of those taking metformin had borderline low vitamin B12 levels compared to 10 percent of those taking a placebo. Jill Crandall, MD, Professor of Medicine at Albert Einstein College of Medicine in New York, shares insights about metformin and vitamin B12. Thank you, Dr. Crandall, for sharing your expertise. To learn more about metformin and diabetes, check out blog posts from other experts in the series. David.