Metformin (500 μM) activates AMPK in hepatocytes, as a result, acetyl-Co A carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed. Metformin (2 m M) activates muscle AMPK and promotes glucose uptake. Metformin (500 μM) or AICAR strongly suppresses SREBP-1 m RNA expression in rat hepatocytes. Metformin ameliorates hyperglycemia without stimulating insulin secretion, promoting weight gain, or causing hypoglycemia. Metformin has beneficial effects on circulating lipids linked to increased cardiovascular risk. Metformin decreases hepatic glucose production and increases skeletal myocyte glucose uptake. Metformin (2 m M) leads to a significant increase in the activity of both α1- and α2-containing complexes in muscle cells. PLEASE NOTE: This treatment is not available through our online pharmacy service. 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