For a small amber or blue oval pill, Zoloft sure generates a lot of buzz -- and so do other members of its family of antidepressants. A study released in 2011 by the National Center for Health Statistics reports that from 2005 to 2008, one in 10 Americans age 12 and older took antidepressant medication, making antidepressants the third most commonly prescribed drug taken by Americans of all ages during and the No. Overall, the rate of antidepressant usage in the U. -- among all ages -- skyrocketed 400 percent between 19 [source: NCHS]. Zoloft -- also known by its generic name sertraline hydrochloride -- is a prescription antidepressant classified as a selective serotonin reuptake inhibitor (SSRI), as we mentioned. This class of antidepressants affects receptors in the brain that absorb serotonin. Serotonin -- 5-Hydroxytryptamine or 5-HT -- is a naturally occurring chemical found in intestines, blood platelets, certain cells and the brain. Serotonin is a derivative of tryptophan, a natural amino acid, and is concentrated in the midbrain and hypothalamus -- two areas responsible for mood, sleep and aggression. When there isn't enough serotonin, either because it is absorbed too quickly or in too great a quantity by the brain's neurons, depression can occur. WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS ZOLOFT and other antidepressant medicines may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Pay particular attention to such changes when ZOLOFT is started or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms. Before taking ZOLOFT, tell your doctor and pharmacist about all prescription and over-the-counter medications and supplements you take or plan to take including: those to treat migraines, psychiatric disorders (including other antidepressants or amphetamines) to avoid a potentially life-threatening condition called serotonin syndrome; aspirin, other NSAID pain relievers, or other blood thinners because they may increase the risk of bleeding. Buy zoloft online uk Ciprofloxacin tinidazole Doxycycline overdose Zoloft is classified as a Selective Serotonin Reuptake Inhibitor. SNRIs, called dual-action antidepressants because they increase levels of serotonin and. Moved Permanently. The document has moved here. May 18, 2017. Did your loved one commit suicide after taking Zoloft. to take corrective action and still continues marketing Zoloft as both effective and safe. Sertraline belongs to a class of medications known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression, panic disorder, and obsessive-compulsive disorder (OCD). Sertraline works by affecting the balance of chemicals in the brain. Specifically, it increases the level of a neurotransmitter called serotonin in the brain. Increased serotonin levels can help improve mood, reduce panic attacks, and treat OCD. Although improvements may occur earlier, the full response to the medication may not appear until after 4 weeks of treatment or longer. This medication may be available under multiple brand names and/or in several different forms. Studies have shown that sertraline has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors. The chronic administration of sertraline was found in animals to down regulate brain norepinephrine receptors. The effect of sertraline on the QTc interval was evaluated in a randomized, double-blind, placebo- and positive-controlled three-period crossover thorough QTc study in 54 healthy adult subjects. At 2-fold the maximum recommended daily dose (~3-fold the steady-state exposure for sertraline and N-desmethylsertraline), the largest mean ΔΔQTc was 10 ms with upper bound of two-sided 90% confidence interval of 12 ms. The length of the QTc interval was also positively correlated with serum concentrations of sertraline and N- desmethylsertraline concentrations. These concentration-based analyses, however, indicated a lesser effect on QTc at maximally observed concentration than in the primary analysis ) of sertraline occurred between 4.5 to 8.4 hours post-dosing. The average terminal elimination half-life of plasma sertraline is about 26 hours. Consistent with the terminal elimination half-life, there is an approximately two-fold accumulation up to steady-state concentrations, which are achieved after one week of once-daily dosing. Zoloft action Depression Treatment ZOLOFT® sertraline HCl Safety Info, Sertraline and alcoholBlood pressure guidelines for 2017Propecia kaufenBuy levitra in perth Buspar vs. Zoloft differences; What is Buspar? What is Zoloft? How do they work mechanism of action? What are the uses for Buspar vs. Zoloft? What are the side effects of Buspar vs. Zoloft? What is the dosage of Buspar vs. Zoloft? What drugs interact with Buspar vs. Zoloft? Are Buspar and Zoloft safe to take during pregnancy or while. Buspar vs. Zoloft Differences, Side Effects, and Uses. Zoloft Suicide Risk & Lawsuits - Drug Law Center. Zoloft sertraline dosing, indications, interactions.. On we'll match the online advertised price for these key competitors chewy.com, petsmart.com, wag.com, walmart.com, target.com, amazon.com, and Find a qualifying product. Make sure the product you would like to price match is identical to our competitor's product. Mechanism of Action. Sertraline potentiates serotonergic activity in the central nervous system through inhibition of neuronal reuptake of serotonin 5-HT. Hundreds of women have taken legal action against Pfizer Inc. the manufacturer of Zoloft, after delivering infants with congenital birth defects and malformations. These lawsuits allege that use of the antidepressant during pregnancy can put a fetus at risk for serious medical problems, some of which are life-threatening.