Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine increse methotrexate Use of chloroquine during pregnancy Plaquenil treatment sle Hcq 200 hydroxychloroquine sulfate May 28, 2009 After a week of the above combination the horrible itching stopped. I still use the three in combination and have not had the itching with this round of plaquinil. Ask your Dr. is my main advice, keep using the lotions that help and know that the itching can be controled. Hopefully eventually to stop! AndiLee did you stop the plaquenil and did it help? I am having the exact same issue with the itching especially after a shower. I have been off for 3 days and the itching hasn't improved yet. For what it's worth, I've been taking generic plaquenil for about 5 years now. Early on, I had an itchy rash break out on my forearms, and my doctor had me stop the plaquenil. Within 4 days, my joint pain returned with a vengance, and I was begging for the plaquenil, itchy rash and all, lol. Over the ensuing years, I've had occasional rashes. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How to stop itching from plaquenil Does anyone have an itchy scalp from hydroxychloroquin or., Does anyone who has RA suffer with itchy skin taking. - NRAS Ara patient information sheet hydroxychloroquineChloroquine lysosomal acidificationChloroquine phosphate and pregnancy With the presistent spread of this hivey rash it sure makes it hard to believe that you will be able to continue the drug. The one thing that might help solve the problem is to stop the plaquenil. If you stop and the rash goes away in a logical period of time and then restart the drug only to have the rash come back. Bingo--you will know. Terrible Itching on Plaquenil---PLEASE HELP.. Itching and plaquenil. Coming Off Plaquenil questions - Sclero Forums MAIN.. Sep 13, 2007 Has anyone else noticed that plaquenil makes them itch? I've been on it for 10 months and I noticed within a couple of weeks that I was pretty itchy. I recently went to the dermatologist for a rash and he said that my rash was from scratching. I think the itch has become worse since I started on Cymbalta. Does anyone else have this problem? May 23, 2016 These include body rashes that often will itch. The rash typically occurs in the first 6 weeks and is usually mild. In general, the rash will resolve within 2 weeks after stopping the drug. A more severe rash affecting larger areas of the body may occur but is not common. How to use Plaquenil. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight.