As with primaquine, tafenoquine can cause severe hemolytic anemia in people with G6PD deficiency. Those with partial deficiency that may be missed by qualitative testing may also be at risk for hemolysis. Hydroxychloroquine how it works Hydroxychloroquine and neutropenia Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex updated, Cerner Multum™ updated, Wolters Kluwer™ updated. Tafenoquine belongs to a group of medicines, called antiprotozoals. It works by treating malaria, a red blood cell infection transmitted by the bite of a mosquito. It also prevents the development of the blood forms of the parasite, which are responsible for the relapse. Tafenoquine is available only with your doctor's prescription. Tafenoquine is in development as a single-dose treatment for relapse prevention in individuals with Plasmodium vivax malaria. Tafenoquine must be coadministered with a blood schizonticide, either chloroquine or artemisinin-based combination therapy ACT. Tafenoquine use in people with G6PD deficiency or unknown G6PD status is contraindicated. Therefore, physicians must perform G6PD testing before prescribing tafenoquine. Act with chloroquine tafenoquine Single-Dose Tafenoquine to Prevent Relapse of Plasmodium., Tafenoquine Advanced Patient Information - Hydroxychloroquine for lupus user reviewsPlaquenil monthsPlaquenil and antiplatelet drugs Tafenoquine is an aminoquinoline that is used in combination with other antimalarials for the prevention of relapse of Plasmodium vivax malaria and by itself as prophylaxis against all species of malaria. Tafenoquine has been linked to low rates of transient and asymptomatic serum enzyme elevations during therapy but has not been associated with instances of clinically apparent acute liver injury. Tafenoquine C24H28F3N3O3 - PubChem. Pharmacokinetic Interactions between Tafenoquine and.. Tafenoquine Uses, Side Effects & Warnings -. The purpose of this two part study is to test the safety and efficacy of Tafenoquine with Cholorquine as a radical cure for Plasmodium vivax P.vivax malaria relative to the control 1 aims to select an efficacious and well tolerated dose that can be co-administered with Chloroquine. The limited evidence available supports both the use of chloroquine and an ACT for P. ovale and P. malariae. ACT seems to be preferable for optimal treatment of P. knowlesi. ACT is at least equivalent to chloroquine in effectively treating non-falciparum malaria. Tafenoquine, a long-acting 8-aminoquinoline drug related to primaquine, was approved by the Food and Drug Administration FDA on July 20, 2018, for antirelapse therapy Krintafel and August 8, 2018, for chemoprophylaxis Arakoda 3, 4.