Some drugs fight inflammation and ease pain, while others help slow disease progression. If there's any comfort in having rheumatoid arthritis these days, it’s that there's a growing number of drugs to deal with its symptoms. Not only can some medications help manage the inflammation, pain, and symptoms of rheumatoid arthritis, but they can stop or slow the progression of the disease, too. Chloroquine osteoarthritis Chloroquine phosphate injection dosage What to do if taking plaquenil makes you nauseous Plaquenil teeth side effects Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Reduces inflammation and cell replication. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. If a patient is resistant to initial DMARD treatment with an agent such as methotrexate, combination DMARD treatment may be used, adding one or more conventional DMARDs leflunomide, hydroxychloroquine, sulfasalazine or a newer biologic treatment to methotrexate. Commonly used oral DMARDs include methotrexate, sulfasalazine, hydroxychloroquine, low-dose prednisone and a newer agent, leflunomide. Other less commonly used DMARDs include azathioprine, cyclosporin and sodium aurothiomalate intramuscular gold. Biological DMARDS, tumour necrosis factor TNF inhibitors, are discussed below. Treatment guidelines from the American College of Rheumatology (ACR) state that early aggressive treatment is the best way to prevent irreversible joint damage and to maintain quality of life for people with rheumatoid arthritis. Traditionally, rheumatoid arthritis treatments have included a combination of DMARDs, or disease modifying anti-rheumatic drugs, that now include different forms of biologics and two other classes of medications: non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. Dmards plaquenil methotrexate DMARDs & Psoriatic Arthritis National Psoriasis Foundation, Traditional Disease-Modifying Anti-Rheumatic Drugs DMARDs Plaquenil for sickle cell anemia In combination with methotrexate for active disease in adult patients when the response to disease-modifying anti-rheumatic drugs DMARDs including methotrexate has been inadequate, or the treatment of severe, active and progressive disease in adults not previously treated with methotrexate or other DMARDs. DMARDs - NICE CKS. Rheumatoid arthritis, monitoring of DMARDs - BPJ 17 October 2008. Perioperative Management of Medications Used in the Treatment.. Methotrexate is usually the first choice DMARD. Methotrexate is usually first line therapy in moderate to severe rheumatoid arthritis because it is effective, has a predictable adverse effect profile, is simple to administer and is inexpensive. 3 In individuals with highly active disease methotrexate may be commenced in combination with other DMARDs. Mild disease may be treated with sulfasalazine or hydroxychloroquine monotherapy. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Methotrexate. Methotrexate MTX, trade names Trexall™ and Rheumatrex™ is the most commonly used DMARD in the treatment of RA, in up to 80% of patients in some studies. MTX is a folic acid analog, which when administered in high doses blocks purine and pyrimidine synthesis.