Prednisolone and pregnancy

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    Prednisolone and pregnancy


    One of the chief concerns of pregnant women with inflammatory bowel disease (IBD) is the effect that the medications to treat IBD may have on an unborn baby. For example, oral steroids such as prednisone are commonly used to treat IBD, and they carry the potential for a host of side effects. Naturally, women with IBD and other inflammatory conditions are going to have questions about taking prednisone during pregnancy. In many cases, medications are clearly needed for pregnant women who have chronic conditions — for the health of both the mother and the baby. If medications like prednisone (corticosteroids) are being recommended by doctors, it means that the risks of the drugs are going to be lower than the risks of not taking any medications. For women with IBD, it is going to be important to be in remission, or to have the IBD as under control as possible before getting pregnant. However, even if a pregnancy is unplanned, there are still many good medication options that can help control IBD inflammation for a pregnant mother. My hematologist in consultation with my ob prescribed 30 mg/day prednisone to increase my declining platelette levels (which have gone down from 169 at 8 weeks of pregnancy to 74 at 37 weeks)so that I can have epudaral as an option during labor/delivery (the anestesiolgist at the hospital would not administer epidural below 90-100K platelette levels, I was told). Do you think this could help increase my platelettle levels and is it a safe way to do so? what potential risks/side effects it could have for me and the baby?? With both I have sufferred from immune thrombocytopenia(low platelet count). Some side effects are extreme hunger, rapid weight gain, hot flashes, heartburn, extreme swelling of your hands, feet, legs and face. Your baby will also gain weight right along with you. A recommendation for the swelling, increase your water intake. It really does help as does elevating your feet and eliminating salty foods and sodas. I'm 37 weeks pregnant with my 2nd child and found out my platelets are low. With my 1st child after delevery I had to have 2 blood transfusions.

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    Taking medications during pregnancy is a reality for many women with IBD. What risks does taking prednisone during pregnancy have on an. Teratogenic effects of synthetic corticosteroids in early pregnancy. In healthy pregnant women taking prednisolone, fetal prednisolone. Prednisolone eye drops should also be administered during pregnancy with great care and in extreme cases, because of the conjunctival cavity prednisolone can be absorbed into the bloodstream. Reviews on the use of prednisolone in pregnancy

    Pregnancy is marked by a state of physiological and hormonal imbalance that affects physical, emotional and psychological aspects of maternal health and wellbeing. But most importantly, a higher degree of caution and care is needed to create the optimum environment for fetal growth and development, which includes minimizing exposure to drugs, chemicals and medications during pregnancy, due to risk of placental transmission and accumulation of these agents in the developing baby. The FDA has categorized drugs into various classes in order to ensure maternal and fetal health. Prednisone - a very popular anti-inflammatory drug - is labeled a Class C drug, suggesting possible risk of fetal harm if consumed during pregnancy. Healthcare providers have varying opinions about the administration of this drug during different trimesters; however, several animal and human experiments did confirm that prednisone is capable of crossing the placental barrier after oral administration. Traditionally, it is recommended to avoid any drug during pregnancy, but it has been observed that certain chronic medical conditions can be exacerbated by pregnancy, and this is especially true for systemic lupus erythematosus, severe and uncontrolled asthma, and rheumatoid arthritis. In addition, certain procedures like organ transplantation require persistent consumption of prednisone to prevent the risk of transplant rejection. Ruiz-Irastorza conducted research to evaluate the risk of developing SLE flares during pregnancy. Prednisolone acetate ophthalmic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile ophthalmic suspension and used to reduce swelling, redness, itching, and allergic reactions affecting the eye. Although there are no major human studies of prednisolone use in pregnant women, studies in several animals show that it may cause birth defects including increase cleft palate. Prednisolone should be used in pregnant women when benefits outweigh the risks and children born from mothers using prednisolone during pregnancy should be monitored for impaired adrenal function. Prednisolone is found in breast milk of mothers taking prednisolone. As a glucocorticoid, the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes.

    Prednisolone and pregnancy

    Prednisolone - Wikipedia, The clinical use of corticosteroids in pregnancy - Oxford Academic.

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  5. In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk. Using prednisone or prednisolone is not expected to significantly increase this background chance. There has been some conflicting information about the use of prednisone/prednisolone during the first trimester.

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    The benefits of using prednisolone during pregnancy will usually outweigh any risks. If taken for long periods or repeatedly during pregnancy. Studies for this narrative review were identified from Pubmed, with the search terms 'glucocorticoids' or 'corticosteroids' or 'prednisone' and 'pregnancy. Along with its needed effects, prednisolone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking prednisolone Some side effects.

     
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