Plasmodium resistance to chloroquine

Discussion in 'Canadian Drugs' started by saygon, 13-Mar-2020.

  1. zxx XenForo Moderator

    Plasmodium resistance to chloroquine


    Rapid diagnostic assays for Pf CRT mutations are already employed as surveillance tools for drug resistance. Here, we review recent field studies that support the central role of Pf CRT mutations in chloroquine resistance.

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    Increased resistance by Plasmodium falciparum parasites led to the withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in Ethiopia. Since 2004 artemether-lumefantrine has served to treat uncomplicated P. falciparum malaria. The Plasmodium falciparum chloroquine resistance transporter is associated with the ex vivo P. falciparum African parasite response to pyronaridine. Parasit. Vectors 9, 77 2016. By treating mice infected with Plasmodium berghei Vincke and Lips, 1948, with increasing doses of chloroquine parenterally, a strain RC was developed which was resistant to the maximum dose of the drug which the host could tolerate.

    Recognition of the value of chloroquine was delayed, and it was not brought forward until it was reevaluated in the United States and designated the drug of choice against malaria near the end of World War II [3]. These studies suggest chloroquine resistance arose in ⩾4 distinct geographic foci and substantiate an important role of immunity in the outcomes of resistant infections after chloroquine treatment. Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency Early in the 20th century, intense demands for an effective quinine substitute launched the discovery and evaluation of a series of organic compounds (beginning with methylene blue), which led to pamaquine and quinacrine after World War I and ultimately produced chloroquine in 1934 [1, 2].

    Plasmodium resistance to chloroquine

    PLASMODIUM VIVAX RESISTANCE TO CHLOROQUINE? - ScienceDirect, Drug resistance in Plasmodium Nature Reviews Microbiology

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  5. Extrusion of chloroquine CQ from digestive vacuoles through the Plasmodium falciparum CQ resistance transporter PfCRT is essen- tial to establish CQ resistance of the malaria parasite.

    • Plasmodium falciparum chloroquine resistance transporter is a..
    • Drug resistance in Plasmodium berghei. I. Chloroquine..
    • Chloroquine Resistance in Plasmodium falciparum Malaria Parasites..

    Plasmodium falciparum parasites have been endemic to Haiti for 40 years without evidence of chloroquine CQ resistance. In 20, we obtained blood smears for rapid diagnostic tests RDTs and filter paper blots of blood from 821 persons by passive and active case detection. Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, Plasmodium falciparum and P. vivax. It is unknown if P. malariae or P. ovale has developed resistance to any antimalarial drugs. The location of study sites with documented chloroquine resistance and chloroquine sensitive P. vivax is shown in Figure 2a and for chloroquine sensitive sites in Figure 2b below. Estimates for chloroquine sensitivity derived from 112 sites. In 50.9% of the sites estimates P. vivax were categorized as resistant.

     
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