Areas with chloroquine or mefloquine resistance

Discussion in 'Canadian Online Pharmacy' started by bobahbi4, 05-Mar-2020.

  1. Favorit XenForo Moderator

    Areas with chloroquine or mefloquine resistance


    Please review the following URL and make sure that it is spelled correctly. This is long, feel free to skip to the end for a tldr.edit: Likewise feel free to skip to symptoms and diagnosis unless you want to read a sleep-deprived dissertation about malaria and mefloquine drug history. If you last looked at malaria a decade or longer ago, you wouldn’t know about knowlesi, he’s ‘new’. malariae guy under the microscope (PCR can tell them apart - it’s a somewhat expensive lab test), but he’s more serious and hangs out exclusively in Southeast Asia. America also has resistance)2011 - AFRICOM issued a policy change for deployments to (sub-Saharan) Africa, barring mefloquine from use, unless malarone and doxycycline cannot be taken or tolerated.

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    For travel to areas where chloroquine resistance is present, mefloquine is the only medication recommended for malaria prophylaxis during pregnancy. Studies of mefloquine use during pregnancy have found no indication of adverse effects on the fetus. Experts are evaluating the safety of atovaquone-proguanil use during pregnancy. Not all of these drugs work equally as well in all areas of the world where there is malaria. The chloroquines, for example, do not work in areas where the malaria parasite has developed resistance to chloroquine. Lariam mefloquine may be effective against malaria that is resistant to chloroquine or other drugs. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

    (and this can and does change every year, depending on the geographical area. The understanding is now that adverse effects can occur/recur years after last dose. It’s the ‘blood cell’ stage, it doesn’t kill the “sleeper cells” (that are part of the P. After swallowing the pill the peak concentration in the plasma is between 6 - 24 hours later. First of all – you may be interested whether this concerns YOU. If you don’t know whether you received mefloquine (or brand name: Lariam) – it’s a pretty unique drug in that it’s a once a week tablet, and you must have deployed to where (at the time) malaria was deemed a threat. CENTCOM followed later for deployments outside Africa.2013 – FDA adds Black Box warning on mefloquine. It’s an advisory that an approved drug has very serious, and/or potentially life-threatening risks, or potentially permanent adverse effects. There has to be serious evidence to the adverse effect(s), and it is the strongest warning the FDA issues.2013 to today – research continues on the central nervous system effects of mefloquine.

    Areas with chloroquine or mefloquine resistance

    Malaria Travel & Health Guide, 2019 Online Book, Lariam Mefloquine Uses, Dosage, Side Effects, Interactions.

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  5. Mefloquine is effective against malaria parasites resistant to chloroquine see INDICATIONS AND USAGE. Drug Resistance Strains of P. falciparum with decreased susceptibility to Mefloquine can be selected in vitro or in vivo. Resistance of P. falciparum to Mefloquine has been reported in areas of multi-drug resistance in South East Asia.

    • Mefloquine - FDA prescribing information, side effects and uses.
    • Chloroquine - Wikipedia.
    • Epidemiology of drug-resistant malaria - The Lancet..

    Following CDC declaration that mefloquine is ‘neurotoxic’ the US military issues policy listing mefloquine as the third choice behind doxycycline and chloroquine for chloroquine-sensitive malaria areas, and doxycycline and mefloquine for areas with chloroquine resistance basically most of S. Asia and nearly all of sub-Saharan Africa. Adult 100 mg chloroquine base once daily always combined with proguanil Travellers should start prophylaxis 24 hours before departure, continue throughout the stay and for at least 4 weeks after return. In areas where resistance to chloroquine is high, chloroquine must be replaced by another effective antimalarial suitable for prophylactic use. Areas with chloroquine resistant P. falciparum High degree, widespread Chloroquine Plus Proguanil as above OR Mefloquine, to be started 2-3 weeks before, continued during exposure and for 4 weeks thereafter OR Doxycycline, to be started 2 days before, continued during exposure and for 4 weeks thereafter, OR Atovaquone Plus Proguanil, to be.

     
  6. jetol Moderator

    The following article looks at the medicinal chemistry of antimalarial drugs. SAR-Structure Activity Relationship authorSTREAM ANTI MALARIAL DRUGS 2014 authorSTREAM SAR of CORTICOSTEROIDS authorSTREAM
     
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