Plaquenil radiation therapy

Discussion in 'Canadian Pharcharmy' started by Petr SA, 21-Feb-2020.

  1. dmitry07 Moderator

    Plaquenil radiation therapy


    Listing a study does not mean it has been evaluated by the U. Giving hydroxychloroquine together with temozolomide and radiation therapy may kill more tumor cells. RATIONALE: Drugs used in chemotherapy, such as hydroxychloroquine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

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    This element can be part of an anti-cancer drug cocktail and I would consider it as an addition next to chemo and/or radiation treatment. However, whenever considering to add to a chemo treatment just perform a short google check of the specific chemo and Chloroquine combo to make sure there is no study indicating antagonism. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving hydroxychloroquine together with temozolomide and radiation therapy may kill more tumor cells. PURPOSE This phase I/II trial is studying the side effects and best dose of hydroxychloroquine when given together with radiation therapy and temozolomide and to see how well they. Problems with Plaquenil Use Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders.

    Cohorts of 3-6 patients receive escalating doses of hydroxychloroquine until the maximum tolerated dose (MTD) is determined. Complete 10 week cycle -Initiation Phase Maintenance cycles 1-6 HCQ daily TMZ D 1-5 150-200mg/m2 every 28 days. cohorts of three pts: dose levels: 200, 400, 800mg. Other: pharmacological study (PK) pts continue on treatment until tumor progression. PKs - correlatives will be collected in Phase 1 Radiation (RT)Phse 2: daily hydroxychloroquine (HCQ) (MTD 600mg) on 1st day of RT and concomitant temozolomide for 6wks during RT. Complete 10 week cycle -Initiation Phase Maintenance cycles 1-6 HCQ daily TMZ D 1-5 150-200mg/m2 every 28 days. Other: pharmacological study (PK) Pts will continue on treatment until tumor progression. PURPOSE: This phase I/II trial is studying the side effects and best dose of hydroxychloroquine when given together with radiation therapy and temozolomide and to see how well they work in treating patients with newly diagnosed glioblastoma multiforme. Complete 10 week cycle -Initiation Phase Maintenance cycles 1-6 HCQ daily TMZ D 1-5 150-200mg/m2 every 28 days. cohorts of three pts: dose levels: 200, 400, 800mg. Other: pharmacological study (PK) pts continue on treatment until tumor progression.

    Plaquenil radiation therapy

    Sarcoidosis - Diagnosis and treatment - Mayo Clinic, Hydroxychloroquine, Radiation, and Temozolomide Treating.

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  7. If you have any questions, contact a member of your healthcare team directly. If you're a patient at MSK and you need to reach a provider after pm, during the weekend, or on a holiday, call 212-639-2000.

    • Hydroxychloroquine Pediatric Medication Memorial Sloan..
    • New Plaquenil Guidelines.
    • Plaquenil - Uses, Side Effects, Interactions -.

    When treating lupus or arthritis, Plaquenil is usually given daily for several weeks or months. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 6 months of treatment. While using Plaquenil, you may need frequent blood tests and vision exams. Free, official coding info for 2020 ICD-10-CM Z79.899 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more. Management of patients with inflammatory rheumatic disease and a history of or even a current malignant disease poses some particular challenges. As direct evidence of the risk of recurrent or de novo malignancy in patients with a history of malignant disease is scarce, such a risk may be estimated indirectly from the principal carcinogenicity of the respective drug to be used or also.

     
  8. Kreal Guest

    My husband has been taking Plaquenil (generic hydroxychloroquine) for almost 2 yrs., under a rheumatologist's care. He became very ill, and was diagnosed w/ viral meningial encephalitis. Plaquenil Oral Uses, Side Effects, Interactions. Do either hydroxychol/Plaquenil put you at. - Plaquenil Hydroxychloroquine - Side Effects, Dosage.
     
  9. LGroup User

    Comparative osmotic fragility of three erythrocyte genotypes. Is put into practical use in the red blood cell osmotic fragi-lity test, which determines the release of haemoglobin from red blood cells in hypotonic sodium chloride NaCl solution. Therefore, osmotic fragility index is a measure of the resistance of red blood cells to lysis by osmotic stress Oyewale and Ajibade, 1990.

    Osmotic lysis of pinosomes - ScienceDirect
     
  10. sy4ok Well-Known Member

    Hydroxychloroquine - Wikipedia Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth.

    Plaquenil - FDA prescribing information, side effects and uses