Volume of distribution of chloroquine

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    Volume of distribution of chloroquine


    Conceptual illustration of effect of drug distribution into tissue space on V: Consider 100 mg of a drug is added to 1 L of water in a beaker under two circumstances and the liquid is sampled for drug concentration (C). , also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.) is possible, and would indicate that the drug is highly distributed into tissue.

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    In our studies, a total of 431 plasma samples were prepared from 22 healthy subjects and 69 patients with vivax malaria for three different studies studies Ia, Ib, and II. In study Ia, a single dose of HCQ sulfate of 400 mg 310 mg as HCQ was administered to six healthy South Korean male volunteers and serial. The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data concentrations being 5 to 10 times higher. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver. Chloroquine diphosphate 3 mg base kg‐1 was given by constant rate intravenous injection over 10 min to 12 healthy adult male volunteers. Plasma concentrations of chloroquine and the principal met.

    Volume of distribution may be increased by kidney failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula. In rough terms, drugs with a high lipid solubility (non-polar drugs), low rates of ionization, or low plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein binding in the body's environment.

    Volume of distribution of chloroquine

    Volume of distribution - Wikipedia, Clinical Pharmacokinetics and Metabolism of Chloroquine.

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  7. Further dividing this by the patient's weight gives us an apparent volume of distribution for Drug B of 0.29 litres per kilogram. The difference between the apparent volumes of distribution of these two drugs is due to their differing lipid vs water solubilities and plasma protein vs tissue binding characteristics.

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    Dec 23, 2012 It therefore easily traverses other tissues and has a large volume of distribution 2100 L. Chloroquine is even more hydrophobic and has one of the highest volumes of distribution of any approved drug 12950 L! This means that, if you take chloroquine, most of the drug is found not in the blood but in tissues like fat. Chloroquine is extensively distributed with an enormous total apparent volume of distribution Vd more than 100 L/kg, and a terminal elimination half-life of 1 to 2 months. As a consequence, distribution rather than elimination processes determine the blood concentration profile of chloroquine in patients with acute malaria. Plasma volumes of distribution up to 65,000 L for chloroquine and 44,257 L for hydroxychloroquine have been reported 71, 75, 77. Normalized by body mass, reported volumes of distribution for chloroquine have ranged from 204 to 800 L/kg depending on the sensitivity of the method of detecting chloroquine.

     
  8. SAPE Well-Known Member

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Plaquenil Risk Calculators
     
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    The study is based on hydroxychloroquine sulfate (the active ingredients of Plaquenil) and Plaquenil (the brand name). Rashes (redness) has been reported by people with rheumatoid arthritis, high blood pressure, multiple sclerosis, hepatitis c, high blood cholesterol. Plaqunil rash - Hydroxychloroquine Side-effects, uses, time to work Hydroxychloroquine Oral Route Precautions - Mayo Clinic
     
  10. Jann User

    Plaquenil Risk Calculators A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight.

    Hydroxychloroquine Blood Levels in SLE Clarifying dosing.
     
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