Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine disadvantages giv Alternatives to plaquenil for lupus Plaquenil dizziness New research finds that measuring blood levels of the medication hydroxychloroquine Plaquenil in people with lupus may be an effective way to predict risk of retinopathy, a disease which results in impaired or complete loss of vision. The study assessed 537 people with lupus and measured the levels of the drug present in their blood. Risk factors that increase the chance of hydroxychloroquine retinopathy include daily dosage, cumulative dose, renal or liver disease, age, and previous retinal disease 9. A daily dose of 6.5mg/kg ideal body weight places patients at higher risk, but a daily dose below this level did not preclude the patient from developing toxicity after many years of treatment. Mar 10, 2017 The risk factors detailed below are recognised to increase the risk of HCQ retinopathy. The sum of risk factors can provide an estimation of risk for a given individual. 40 Some risk factors are. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Risk of plaquenil retinopathy The risk of toxic retinopathy in patients on long-term., Hydroxychloroquine Plaquenil Toxicity and Recommendations. What company makes plaquenil May 16, 2011 Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists. Hydroxychloroquine Retinopathy Still Alive and Well - The.. Hydroxychloroquine retinopathy Eye. Retinopathy Risk in Lupus Increases With Longer.. Hydroxychloroquine and CQ retinopathy can progress even after the drugs are stopped, although the amount of progression and the risk to vision are functions of the severity of retinopathy at the time it is detected. 5,11 It seems doubtful that this late progression of damage after stopping the drug results from a continued reservoir of the drug, although clearance from the body does take many late progression may represent a gradual decompensation of cells that were injured. Marmor MF, Kellner U, Lai TYY, Melles RB, Mieler WF, for the American Academy of Ophthalmology. Recommendations on screening for chloroquine and hydroxychloroquine retinopathy 2016 revision. Ophthalmology 2016;186-1394. Melles RB, Marmor MF. The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. Feb 19, 2020 Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days.