Hi Dr V, I am at a crossroad of considering to go back on Plaquenil . A year ago I proposed to go off Plaquenil after being on it for 22 years. Aralen dosage malaria prevention Plaquenil eye screening guidelines Chloroquine lichen planus Plaquenil hair changes Plaquenil pla´kwĕ-nil trademark for a preparation of hydroxychloroquine, an antiinflammatory and antiprotozoal agent used for treatment of malaria, lupus erythematosus, rheumatoid arthritis, and giardiasis. With a half-life of 537 hours 22.4 days. In the same study, the plasma peak concentration was. 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug. The one thing that concerns me about the Plaquenil is the half life is about 50 days. So, after even just a couple weeks on it.would take you many months for it to leave your system. Also, you should get a baseline eye test before or shortly after starting the Plaquenil. And, then yearly exams after that to check for Retinopathy. If I had joint or muscle aches, I took care of it by resting, Aleve and ice. At my recent eye exam the doctor mentioned I had reached the plaquenil toxicity level and that my retina cells could die (which do not regenerate! My proposal was based on the fact that I had not had any major inflamation that completely shut me down or keep me from being active. What is the half life of plaquenil Plaquenil hydroxychloroquine sulfate dosing, indications., PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION Plaquenil icd 10Pharmacokinetics chloroquine miceEffects of plaquenil on liverHow long until hydroxychloroquine worksIs mefloquine hydroxychloroquine Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Hydroxychloroquine Sulfate Drug Information, Professional. Minocycline and plaquenil. Taking Plaquenil for Rheumatoid Arthritis. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The absorption half-life was approximately 3 to 4 hours and the terminal half-life ranged from 40 to 50 days. The long half-life can be attributed to extensive tissue uptake rather than through decreased excretion. Peak plasma levels of hydroxychloroquine were seen in about 3 to 4 hours. It is now 6 weeks later, I've titrated up to 600mg. per day, and I am SEVERELY depressed, to the point I can't get out of bed some days. I am sicker mentally than I have been for 16 years, and it didn't start until I started the plaquenil. I'm so anxious, I'm agoraphobic and having anger attacks. I have never been agoraphobic in my life.