To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation. Hydroxychloroquine and ra Plaquenil affect immune system Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. Apr 30, 2013 SD-OCT scan from a 44-year-old woman with bilateral plaquenil toxicity. There is damage visible in the outer retina in a perifoveal distribution. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. Main Outcome Measures: SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Retrospective clinical data review by the Boston Image Reading Center. Plaquenil oct damage What can Hydroxychloroquine Plaquenil do to my eyes?, Plaquenil Toxicity - Retina Image Bank Hydroxychloroquine for osteoarthritis She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to presentation. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Protecting your eyesight when taking Plaquenil Lupus.. Recommendations on Screening for Chloroquine and.. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, dizziness, trouble breathing. This is not a complete list of possible side effects. Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Thirteen patients were excluded because an OCT was not performed at the time of diagnosis. Eight patients were excluded for having a time domain-OCT at the time of drug cessation. Thirty eyes of 15 female patients met inclusion criteria and were followed by repeated examinations after drug cessation.