While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "Hydrochloroquine (Plaquenil) has been a blessing for me. Side effects of chloroquine in pregnancy Plaquenil retinal testing guidelines Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first; even when your symptoms improve to help keep the disease under control. Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. It's still not terribly long since you started Plaquenil. Many of us found it a slow process and yes there were times we thought we were winning and then another flare came along. Ideally after 6-9 months you can guage it's effectiveness properly but you will still probably need a good NSAID to help out. I do occasionally experience dry eyes and a little scalp itch but asserting that it's caused by Hydrochloroquine would be anecdotal at best. It took about 5 weeks to take effect but my RA is basically a non factor now. When plaquenil doesn t work Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Ask the Expert Plaquenil and Sjögren’s Chloroquine resistance map malaria 2015Plaquenil vs rituximab rituxanWhat chloroquine Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain. Immune & Autoimmune - Lupus Plaquenil not working anymore. If Plaquenil doesn't work. Lupus Forums at The Lupus Site. Despite Plaquenil dosing recommendations, retinal toxicity.. Does anyone take methotrexate and hydroxychloroquine and has anyone had problems with hydroxychloroquine. No joke I had to come off purely because I thought I was going to take off in work. Not good for credibility let me tell you xxxx Fi. Reply 0 Report. Hidden. in reply to Hidden. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Plaquenil is supposed to help with hair loss, not contribute to it. I would also suggest giving it some more time especially since the side effects of plaquenil are supposed to lessen after a few months of use.