The recurrent, painful tightening usually occurs in the calf muscles and can cause severe insomnia. The exact mechanism is unknown, but the cramps are probably caused by muscle fatigue and nerve dysfunction rather than electrolyte or other abnormalities. Plaquenil and eye exams Chloroquine synthesis mechanism Plaquenil “ Side Effects Dizzy, upset stomach, back pain and side pain, abdominal cramps, leg cramps, rapid heart rate, anxiety and body felt covered in bruises. Tell us about your Experience with Hydroxychloroquine Sulfate Related Muscle Spasms. Effectiveness. Overall. I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea. Warning. Oral route Capsule Quinine sulfate use for the treatment or prevention of nocturnal leg cramps may result in serious and life-threatening hematologic reactions, including thrombocytopenia and hemolytic uremic syndrome/thrombotic thrombocytopenic purpura HUS/TTP. Chronic renal impairment associated with the development of TTP has been reported. Medications that are strongly associated with leg cramps include intravenous iron sucrose, conjugated estrogens, raloxifene, naproxen, and teriparatide. Nocturnal leg cramps are associated with vascular disease, lumbar canal stenosis, cirrhosis, hemodialysis, pregnancy, and other medical conditions. Does plaquenil cause leg cramps Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Stomach problems with Plaquenil • Johns Hopkins Arthritis. Feeling weird just started taking hydroxychloroquineWhat is the difference between chloroquine and chloroquine phosphate Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Quinine Side Effects Common, Severe, Long Term -. Plaquenil vs. Azulfidine Prescription Treatment for.. She started me on the generic version of Plaquenil at 200 mg. I have had a really hard time on this medicine. I have had extreme nausea, diarrhea, stomach cramps, and intense vertigo. I began taking it on Thanksgiving day and still experience these side effects. A week ago I asked if there was anything we could do and she stated that this was t. If you don't mind, could you tell me something? Do most people with RA continue to work full-time? I do, except that I called in sick today because I was up all night with leg cramps, but I'm finding it extremely difficult to stay awake for an eight hour day. I'm 52 and can't retire yet so I'm wondering what people do to make it through the day? And, as far as Plaquenil and eye problems, the Ophthamologists I've talked to including a Neuro Ophthalmologist say that while Plaquenil can cause serious damage to the optic nerve, it's very rare. Annual appointments with an ophthalmologist are important in order to catch any problems early.