Newer studies have preferred practice protocols be changed to using spectral-domain OCT technology as the main screening device for detection of early retinal changes in plaquenil toxicity. The patient reported that she was in reasonably good health despite a long-term history of lupus. Chloroquine production process Symptoms of plaquenil Chloroquine long qt Disease EntityDiagnosisManagementAdditional ResourcesReferences Symptoms and SignsMechanism of ToxicityMedication DosageRisk For ToxicityMonitoring GuidelinesConclusion To analyze Humphrey visual field HVF findings in hydroxychloroquine HCQ retinal tests were interpreted retrospectively in this observational case series of 15 patients with HCQ toxicity. Patients seen at Lahey Clinic were identified by. In addition to medication for her lupus, she was also being treated with glyburide for diabetes and an unkown medication for hypertension. She was taking 200 milligrams of plaquenil per day to treat her lupus and had been on this dose level for the past twenty years. Plaquenil maculopathy visual field Early Plaquenil Toxicity Detected without Bull’s Eye., Hydroxychloroquine-Induced Retinal Toxicity - American. What are the ingredients in hydroxychloroquineChloroquine aralen side effectsChloroquine malaria treatmentPlaquenil diarrhea nauseaChloroquine pregnancy category To analyze Humphrey visual field HVF findings in hydroxychloroquine HCQ retinal toxicity. HVF tests were interpreted retrospectively in this Humphrey visual field findings in hydroxychloroquine.. Humphrey visual field findings in hydroxychloroquine toxicity. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Nov 01, 2015 SHIRI SHULMAN, MD. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity. The multifocal electroretinogram mfERG can provide objective corroboration for visual fields, and fundus autofluorescence FAF can show damage topographically. Modern screening should detect retinopathy before it is visible in the fundus. Toxicity Retinopathy is not reversible, and there is no present therapy. Recognition at an early stage before any RPE loss is important to prevent central visual loss. Diagnosis of a toxic reaction was based on assessment of visual field findings according to the criteria outlined by Bernstein, 3 where acceptance of a case as a valid retinopathy requires as a minimum the presence and persistence of central or paracentral visual field scotomas to suprathreshold white stimuli and a duration of treatment of at least 9 months with a daily dose of hydroxychloroquine sulfate of 400 mg or less.