Lysosomotropic agent chloroquine

Discussion in 'Certified Online Canada Pharmacy' started by balezin, 08-Mar-2020.

  1. N1k0laj Well-Known Member

    Lysosomotropic agent chloroquine


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    Chloroquine CQ is a lysosomotropic agent with an extensive range of biological effects 1. Historically known for its anti-malarial activity, chloroquine is a widely used biological research tool for studying autophagy inhibition. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH. Aug 24, 2017 There has been long-standing interest in targeting pro-survival autophagy as a combinational cancer therapeutic strategy. Clinical trials are in progress testing chloroquine CQ or its. Such substances are referred to as lysosomotropic agents, and via this mechanism, trapped substances may accumulate to concentrations hundredfold that of the cytosolic concentration 22 Figure 1. Several well-known drugs used in the clinic have documented lysosomotropic abilities including the antimalarial drug chloroquine, several

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Lysosomotropic agent chloroquine

    Lysosomal Disruption Augments Obinutuzumab-Induced Direct., Lysosomotropism depends on glucose a chloroquine resistance.

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  7. Chloroquine is also a lysosomotropic agent, meaning it accumulates preferentially in the lysosomes of cells in the body. The pK a for the quinoline nitrogen of chloroquine is 8.5, meaning it is about 10% deprotonated at physiological pH as calculated by the Henderson-Hasselbalch equation. This decreases to about 0.2% at a lysosomal pH of 4.6.

    • Chloroquine - Wikipedia.
    • Lysosomotropic agents impact on lysosomal membrane..
    • Chloroquine treatment of ARPE-19 cells. - PubMed Central PMC.

    Rationales for lysosomotropic amines. Chloroquine is a diprotic weak base pK a1 = 8.1, pK a2 = 10.2 at 37°C that can exist in both protonated and unprotonated forms Figure 2 and Table 2. Unprotonated chloroquine can diffuse freely and rapidly across the membranes of cells and organelles to acidic cytoplasmic vesicles late endosomes and. Chloroquine is a known lysosomotropic agent that increases lysosomal pH by accumulating within lysosomes as a deprotonated weak base. To study the effects of lysosomal dysfunction in ARPE-19, it was necessary to establish an in vitro model utilizing chloroquine. We determined the concentration of chloroquine that substantially changed lysosomal activity, but did not result in cell necrosis. Chloroquine has been used for decades for the treatment of malaria and rheumatoid arthritis, and has been shown to achieve some level of anti-HIV activity. Chloroquine is also known to be an inhibitor of autophagy by blocking acidification of the lysosome, preventing fusion with autophagosome and, thus, represents a clinical opportunity.

     
  8. Diba84 Moderator

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil, Plaquenil Sulfate, Quineprox hydroxychloroquine. Hydroxychloroquine Sulfate - an overview ScienceDirect Topics Hydroxychloroquine MedlinePlus Drug Information
     
  9. 2pro2 Guest

    The following information is NOT intended to endorse any particular medication. Plaquenil for Psoriatic Arthritis? - Psoriasis - Inspire Hydroxychloroquine in psoriatic arthropathy exacerbations. Hydroxychloroquine Plaquenil
     
  10. Poserdonn Moderator

    MorrowindAncestral Tombs - The Unofficial Elder Scrolls. Arenim Ancestral Tomb — A large tomb on Azura's Coast south of Sadrith Mora, east of the Erabenimsun Camp, and close to the Holamayan monastery. map Quest Related Arethan Ancestral Tomb — A small tomb in the mountains of Molag Amur.

    MorrowindGrazelands - The Unofficial Elder Scrolls Pages UESP
     
  11. simon Moderator

    Taking Plaquenil for Rheumatoid Arthritis Plaquenil hydroxychloroquine is an older DMARD used to treat certain rheumatic conditions. Learn about its safety, side effects, and benefits.

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