If so, how long does it take to make pain and stiffness go away? My dr is using it trying to get rid of all of my joint pain and stiffness that seems to be taking over my body. I had a pretty bad flare right after Christmas and my rheumy added methotrexate to what I was already taking. I don't know for sure if it is the plaquenil or other meds but my rheumy seems to have my inflammation/stiffness under pretty good control. Just rediced plaquenil from one tablet twice a day to one tablet once a day. I have noticed an improvement but it's very little. Reticulocytes chloroquine treatment p62 Chloroquine concentration Splitting hydroxychloroquine Does plaquenil suppress immune system further in an immunosuppressed person I looked back through my lab work. Even while taking 400mg of Plaquenil and 15mg of Prednisone also an immunosuppressant, my immune system was still overactive. My Absolute Neutrophils good indicator of immune system function didn't get suppressed to a NORMAL range until I increased the Plaquenil to 600mg/day while still taking the Prednisone. Hydroxychloroquine Plaquenil – American College of Rheumatology – It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Severe depression and anxiety, overall itching, pain and stiffness increased instead of decreased First, my mother and sister took plaquenil for lupus with good effect, so I am not just disliking it for no good reason. I also suffer from disabling bipolar disorder. For 25 years, I have gotten hypomanic during spring. Very happy, never depressed. He encouraged me to stay with it 3-4 months in order to get the full effect of any help I may receive. However, I think I may be getting migraines from it?! Just remember everyone has a different reaction to the various meds. I don't know if the plaq or MTX or prednisone is what's helping. Plaquenil takes quite a long time to get to its peak effectiveness: depending on what you read, anywhere from 3 months to a year. I also take Cimzia injections bi-weekly but that has only been for about 6 months. Although I do have to give credit to my rheumy because after just a month or two I wanted to be taken off the Cimzia as I didn't think it was really doing much. Hi brandi, I tried Plaquenil, unfortunately for me the side effects is what took me off of it. The kind where I wanted to scratch every inch of my skin off. Took about a week of taking 2 kinds of allergy meds before I got rid of that effect. I have 2 days a week, after my MTX, where I'm just sick. I've been on the MTX now for about a month and when I see my rheumy in 2 weeks I'm going to see if I can try something else or stop taking it. Plaquenil and muscle stiffness Lupus Do you still have joint and muscle pain on plaquenil?, How Does Plaquenil Work For Rheumatoid Arthritis Plaquenil and melatoninDoes plaquenil have life long effectsPlaquenil sulfate usesLove plaquenilAbruptly stopping plaquenil Home remedies for joint pain and stiffness include taking a warm shower or bath, or applying a heating pad or ice pack. Apply ice if your joint is inflamed. Rest can also relieve these two common lupus symptoms. Avoid putting weight on the affected joint, or performing any activity that stresses it, and support it with a pillow or cushion. Coping with Common Lupus Symptoms and Treatments. PLAQUENIL Side Effects, Reviews by Patients -. In MG/Lupus Overlap, Thymus May Play Key Role, Case Series.. Rheumatoid arthritis is a form of arthritis with inflammation of the joints, characterised by stiffness, swelling and pain. Plaquenil may be used for short or long-term rheumatoid arthritis treatment. Muscle weakness also may be a side effect of certain drugs used to treat lupus and related conditions, including prednisone and other corticosteroids, cholesterol-lowering drugs and hydroxychloroquine Plaquenil®. Therefore, drug-induced muscle disease should be ruled out as a cause of weakness if you are taking any of these medications, as drug-induced muscle weakness usually does not produce elevated levels of muscle enzymes as is seen in lupus myositis. I don't know for sure if it is the plaquenil or other meds but my rheumy seems to have my inflammation/stiffness under pretty good control. Been taking plaquenil and arava for about a year. Just rediced plaquenil from one tablet twice a day to one tablet once a day. I also take Cimzia injections bi-weekly but that has only been for about 6 months.