Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine porphyria cutanea tarda Hydroxychloroquine for autoimmune diseases Plaquenil weight gain at 400mg Chloroquine gametocidal Feb 19, 2020 Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil pain medication Medications used to treat lupus Lupus Foundation of America, Hydroxychloroquine Plaquenil Can i take plaquenil with percocetChloroquine hydrochloride dosage It belongs to a class of medications known as disease-modifying antirheumatic drugs DMARDs. It can reduce skin problems in lupus and prevent swelling/pain in arthritis, though it is not known. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Plaquenil and pain" Rheumatoid Arthritis Community.. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Drugs which may interact with Plaquenil include antacids. botulinum toxins. digoxin. kaolin. magnesium trisilicate. methotrexate. metoprolol. penicillamine.