The following symptoms require medical attention, but are not an emergency. However, you should always inform your health care provider if you experience any unusual symptoms. (For more detail, see "How Letrozole Works" section below). Some that are rare (occurring in less than 10% of patients) are not listed here. Contact your health care provider within 24 hours of noticing any of the following: You will be monitored regularly by your doctor while you are taking letrozole, but no special tests or blood tests are required. Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. For example, the hormone testosterone made in the testicles and is responsible for male characteristics such as deepening voice and increased body hair. 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