Based on PBPK models results, a loading dose of 400 mg twice daily of hydroxychloroquine sulfate given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days is recommended for SARS-Co V-2 infection, as it reached three times the potency of chloroquine phosphate when given 500 mg twice daily 5 days in advance. It's important to note that the study was examining use of chloroquine and hydroxychloroquine for treatment and prophylaxis of Covid19 infection (anti-viral activity) as well as postulating immuno-modulatory benefits against the 'cytokine storm' which precipitates later ARDS-type respiratory failure. Chloroquine rheumatoid arthritis Doxycycline rosacea and plaquenil PLAQUENIL. Plaquenil Information. Plaquenil Hydroxychloroquinine is commonly used for the treatment of certain auto-immune diseases. It is believed that it acts through interfering with the normal processes of the organism of producing and releasing the specific blood cells involved in the immune defense system. The central clinical TF will recommend antiretroviral agents Kaletra, antimalarial agents Chloroquine, and Hydroxychloroquine as the primary antiviral drugs for COVID-19. Ribavirin and Interferon, which are mentioned as COVID-19 drugs, have relatively high side effects and are not recommended as primary antiviral drugs. In particular, some patients confirmed that they could be cured by au\ Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. As a doc with RA, I know that when my hydroxychlorquine dose is upped, I have to take the long view of 3 months when considering if it has helped with inflammation. The immunomodulatory benefits in the short term are not convincing since hydroxychloroquine used in a clinical setting for auto-immune disease is known to be maddeningly slow to show benefit. Is hydroxychloroquine antiviral Hydroxychloroquine DermNet NZ, COVID-19 primary antivirals KaletraChloroquine recommended Hydroxychloroquine reviews Hydroxychloroquine, hydroxyurea and didanosine as initial therapy for HIV-infected patients with low viral load safety, efficacy and resistance profile after 144 weeks. New insights into the antiviral effects of chloroquine.. Hydroxychloroquine - Wikipedia. In Vitro Antiviral Activity and Projection of Optimized Dosing Design.. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2 – a publication from March 2020 indicating that Hydroxychloroquine was more potent than Chloroquine. The publication further proposes the following treatment schedule. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America. Hydroxychloroquine comes in 200 mg tablets and is taken orally. The dose provided will be based upon a calculation of 6.5 mg/kg subject’s weight, which is the dose range commonly used to treat rheumatoid arthritis and lupus.