Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Chloroquine cancer therapy Plaquenil sun Plaquenil therapy lupus Plaquenil savings card Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquinel was one of the earlier drugs I took for RA and it did not work. Methotrexate pills did not work either. My doctor switched me to Methotrexate injections before going to the bigger guns. It works along with antibotic theraphy. Plaquinel has side effects too, it is just a decision you need to make as it is your body. Does anyone know if hydroxychloroquine and methotrexate can cause weight loss day, been taking for over a year now but although it helps with some of the pain. I have to have steroid. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Does plaquenil work without methotrexate Rheumatoid Arthritis Treatment Options Johns Hopkins., Methotrexate or Plaquenil? DailyStrength Hydroxychloroquine monitoring eye Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Methotrexate vs Plaquenil Comparison -. Does anyone take methotrexate and hydroxychloroquine.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil hydroxychloroquine and Rheumatrex and Trexall methotrexate are used to treat rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Rheumatrex and Trexall are also used to treat some cancers and severe skin diseases such as severe psoriasis. They had my on plaquenil initially for seronegative RA and it didn't help with my symptoms - I also had similar side effects and lost some hair which isn't ideal when you're 21 lol I'm on methotrexate now and I have some GI side effects and brain fog and whatnot, but they're tolerable. No methotrexate doesn't always mean your hair will fall out or thin but some of the side effects are scary, but before you an progress onto other meds methotrexate is mandatory. for me methotreaxte and plaquenil does't work and i' intonate of sulfa so i am started embrel which states you have to have tried 2 of 3 meds and methotrexate is 1 of them.