Pfcrt chloroquine resistance

Discussion in 'Chloroquine Phosphate' started by Kroff, 10-Mar-2020.

  1. esudnik User

    Pfcrt chloroquine resistance


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    It has been shown that chloroquine resistant strains can efflux chloroquine from the digestive vacuole upto 40 times faster compared to chloroquine sensitive strains 18. The increased rate of chloroquine exiting the DV has beed associated to a mutation in plasmodium falciparum chloroquine resistant promoter PfCRT gene. PfCRT gene is found. Chloroquine CQ was the cornerstone of anti-malarial treatment in Africa for almost 50 years, but has been widely withdrawn due to the emergence and spread of resistance. Recent reports have suggested that CQ-susceptibility may return following the cessation of CQ usage. Here, we monitor CQ sensitivity and determine the prevalence of genetic polymorphisms in the CQ resistance transporter gene. Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial drug, is mediated primarily by mutant forms of the chloroquine resistance transporter PfCRT. These mutations impart upon PfCRT the ability to efflux chloroquine from the intracellular digestive vacuole, the site of drug action.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Pfcrt chloroquine resistance

    Pfcrt - Chloroquine resistance transporter - Plasmodium., Return of chloroquine sensitivity to Africa? Surveillance.

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  7. Nov 27, 2019 Structural, functional and in silico analyses of the chloroquine-resistance transporter PfCRT of Plasmodium falciparum suggest that distinct mechanistic features mediate the resistance to.

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    The emergence and spread of chloroquine-resistant Plasmodium falciparum malaria parasites has been a disaster for world health. Resistance is conferred by mutations in the Chloroquine Resistance Transporter PfCRT, an integral membrane protein localized to the parasite’s internal digestive vacuole. Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial drug, is mediated primarily by mutant forms of the ‘Chloroquine Resistance Transporter’ PfCRT. These mutations impart upon PfCRT the ability to efflux chloroquine from the intracellular digestive vacuole, the site of drug action. Abstract. The development of chloroquine as an antimalarial drug and the subsequent evolution of drug-resistant Plasmodium strains had major impacts on global public health in the 20th century. In P. falciparum the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in PfCRT, a protein that likely functions as a transporter in the parasite’s.

     
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