Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine diphosphate salt lysosome inhibitor Accidental double dose of plaquenil The emergence of chloroquine resistance has been associated with a dramatic increase in malaria mortality among inhabitants of some endemic regions. The rationale for chemoprophylaxis is weakening as multiple‐drug resistance develops against well‐tolerated drugs. Plasmodium falciparum drug‐resistant malaria originates from chromosome mutations. Resistance to chloroquine, in the case of P. falciparum, is linked to mutations in the P. falciparum chloroquine resistance transporter pfcrt gene, which alters the transport and accumulation of the drug in the digestive vacuole DV of the parasite 7, 8. Drug transport is believed to be of crucial importance for understanding the mechanisms of chloroquine resistance, as it is clear that less chloroquine accumulates in chloroquine-resistant parasites than in chloroquine-sensitive parasites. It was originally thought that this lack of accumulation was the result of an efflux mechanism, and a. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine mechanism of drug action and resistance in plasmodium falciparum Chloroquine Mechanism of drug action and resistance in., Antiplasmodial activity of chloroquine analogs against. Can hydroxychloroquine cause high blood glucose levelsDoes hydroxychloroquine work as well as plaquenilLysosome fusion inhibitor chloroquine On the Mechanism of Chloroquine Resistance in Plasmodium falciparum Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. On the Mechanism of Chloroquine Resistance in Plasmodium falciparum. Malaria Dissecting chloroquine resistance - ScienceDirect. Update Chloroquine-Resistant Plasmodium falciparum -- Africa. In the pharmacological features of the chloroquine resistance in P. falciparun, namely the proposed efflux mechanism and the reversal of resistance by verapamil, desipramine and related compounds led to the proposal that a similar mechanism for drug resistance was operating in P. falciparum. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy.