Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Hydroxychloroquine internal bleeding How long before hydroxychloroquine starts working Hydroxychloroquine nursing teaching More in Eye Health. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. A Disorder Of The Retina Of The Eye; Co-administration of PLAQUENIL with other antimalarials known to lower the convulsion threshold e.g. mefloquine may increase the risk of convulsions. Antiepileptics The activity of antiepileptic drugs might be impaired if co-administered with PLAQUENIL. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Risks of plaquenil Hydroxychloroquine Oral Uses, Side Effects, Interactions., Common and Rare Side Effects for Plaquenil Oral Does hydroxychloroquine help osteoarthritisDoes hydroxychloroquine interact with potassiumChloroquine diphosphate salt solubilityLupus nephritis and plaquenilPlaquenil is taken with or without food Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. Rx Side Effects New Plaquenil Guidelines and More - American.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Long-Term Side Effects of Plaquenil for Rheumatoid.. If common side effects do occur, they are usually minor and last only for a short period of time. Please note the rare side effects listed below, specifically retinopathy, which causes damage to the eyes. Side effects associated with Plaquenil are placed in three categories common, less common, and rare. What Are Side Effects of Plaquenil? nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, ringing in your ears, Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes.