Methotrexate is one of the most commonly used drugs to treat RA. However, it can decrease the levels of an important vitamin in your body called folate. Chloroquine mechanism of action in sle Tab chloroquine brand name Off label uses of plaquenil Background 34 year old mother of 2 diagnosed in December with RA high RF and Anti-CCP. I'm on methotrexate injections just recently increased to 20 mg and plaquenil 200 mg twice a day. And folic acid. Early December I received a steroid injection to help with the pain/inflammation and improve my mobility temporarily. Oct 09, 2015 Hi, I have Raynaud's syndrome since 2010, and in 2014 I had a blood test with the result of positive ANA speckled and ACA, ACA-B. I still don't have thickening skin of the hands/fingers, but my doctors told me I have Limited Systemic Scleroderma, since anti centromere antibody ACA is a very specific scleroderma auto-antibody. Methotrexate is a potent folic acid antagonist and so many doctors prescribe folic acid to help with the side effects of methotrexate, such as nausea. But she has MTHFR and folic acid is toxic for her, hence he switched her to the methylated version, L-5-Methylfolate. Side effects can develop if the methylfolate dose is too high. Your doctor may suggest you take a folic acid supplement, which is a manufactured form of folate. This leads to a side effect of methotrexate called folate deficiency. Methotrexate and folic acid and plaquenil for lupus Compare Plaquenil vs Methotrexate -, Methotrexate and plaquenil - @Kristinsaba1988 - Scleroderma. What does plaquenil tratDoes plaquenil cause skin peeling on handsHydroxychloroquine 400 mgWhat is chloroquine made of Protocolled treatment of RA patients at both clinics consisted of MTX 25 mg/week reaching maximum dose within 4–8 weeks, preferably subcutaneously, and HCQ 400 mg/day as soon as feasible after diagnosis. Folic acid 10 mg/week is standard-prescribed to minimize MTX side effects. Effects of methotrexate and hydroxychloroquine combination therapy vs.. Methotrexate MTHFR folic acid Lupus Forums at The Lupus Site. Taking Folic Acid with Methotrexate What Patients Need to Know. Low dosages of Methotrexate Rheumatrex, such as 7.5 mg given orally once per week, are extremely effective in the treatment of lupus. Methotrexate can be given orally drops mixed with water or by subcutaneous injection once a week. It is now standard practice to use folic acid to counter some of the minor side effects of Methotrexate. Compare Hydroxychloroquine vs. Methotrexate, which is better for uses like RA, Lupus and Arthritis. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. The good news These common side effects can often be short-circuited by taking a folic acid supplement. Folic acid is the synthetic form of folate. One study found that rheumatoid arthritis RA patients on methotrexate who took folic acid supplements lowered the risk of GI problems and mouth sores by 79 percent.