In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Hydroxychloroquine sulphate tablets zy-q 300 Does plaquenil treat scleroderma Can chloroquine help rheumatoid arthritis How does hydroxychloroquine help sjogren's Crohn’s disease Complications of Crohn’s can include gum inflammation and cavities, but the most common are mouth sores or canker sores. Coeliac disease gluten intolerance Non-steroidal anti-inflammatory drugs NSAIDs This may include such medications as ibuprofen, aspirin, Celebrex, ketoprofen, naproxen, and diclofenac. Teeth or gum problems, related to Lupus? deleted_user 05/22/2011. This may be a silly question but does anyone have problems with their gums from Lupus? My gums in my mouth have been getting inflamed and sore. never had a problem with them before. Have had 4 teeth pulled though. Usually, the pigment is brown to black. 18,19 Nonmelanic pigmentation occurs when the nail matrix extracts the drug and stores it in the nail, or the drug deposits in the nail or subungual area. The nail may turn blue, brown, or gray, depending on the drug, and the color will grow out as the nail does. 1,20,21 As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Plaquenil and black gums Plaquenil - Uses, Side Effects, Interactions -, Teeth or gum problems, related to Lupus? DailyStrength Hydroxy chloroquineHydroxychloroquine temporal arteritis A person with lupus demonstrates increased levels of xerosthemia or dry mouth leading to increased levels of caries, periodontitis and candidiasis. The gingival tissue may become red and appear to be desquamating. What are called leukoplakic lesions white scaly tissue detaching from the underlying tissue. Dental Concerns - Lupus International. Drug-Induced Nail Changes Counting to 10. Dark Spot in the Mouth — Is It Cancer? - Oral, Head, and.. Answer. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. It reveals itself as crusting of the lips usually symmetrical and as painful ulcerations of the gums, lips, cheeks, tongue. Swollen glands, fever, and genital lesions may also occur. You should contact a doctor as soon as you realize you are having this reaction, or go straight to the emergency room. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others.