Return of chloroquine antimalarial efficacy in malawi

Discussion in 'Chloroquine Without A Doctors Prescription' started by driver2008, 04-Mar-2020.

  1. Denlos Guest

    Return of chloroquine antimalarial efficacy in malawi

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    Recommended drugs for each country are listed in alphabetical order and have comparable efficacy in that country. No antimalarial drug is 100% protective and must be combined with the use of personal protective measures, i.e. insect repellent, long sleeves, long pants, sleeping in a mosquito-free setting or using an insecticide-treated bednet. However, the spread of resistance may be reversible. Malawi was the first country to discontinue chloroquine use due to widespread resistance. Within a decade of the removal of drug pressure, the molecular marker of chloroquine-resistant malaria had disappeared and the drug was shown to have excellent clinical efficacy. Chloroquine CQ was the cornerstone of anti-malarial treatment in Africa for almost 50 years, but has been widely withdrawn due to the emergence and spread of resistance. Recent reports have suggested that CQ-susceptibility may return following the cessation of CQ usage.

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    Return of chloroquine antimalarial efficacy in malawi

    Return of Chloroquine Antimalarial Efficacy in Malawi., The return of chloroquine-susceptible Plasmodium falciparum.

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  6. In a study of chloroquine efficacy in Kenya and Malawi in the early 1980s, 75 and 82% of infections were found to be resistant to chloroquine in vivo Bloland et al. 1993. As chloroquine resistance rates increased in Africa, so did morbidity and mortality attributable to malaria Zucker et al. 1996, Zucker et al. 2003, Trape et al. 1998.

    • Withdrawing antimalarial drugs impact on parasite resistance..
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    • Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health CDC.

    Malawi’s transition from piloting interventions to national scale-up of those efforts, aided by monitoring and evaluation activities, helped make Malawi a regional success story. CDC’s Malaria Branch has engaged in a cooperative agreement with Malawi’s College of Medicine/Malaria Alert Centre COM/MAC since 2004. The spread of drug-resistant Plasmodium falciparum malaria has been a major impediment to malaria control and threatens prospects for elimination. We recently demonstrated the return of chloroquine-susceptible malaria in Malawi after chloroquine use was abandoned. Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. Return of chloroquine antimalarial efficacy in Malawi. N Engl J Med 355.

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    Plaquenil 200mg Hydroxychloroquine - Hydroxychloroquine in Plaquenil tablets 200mg is thought to act by inhibiting the formation of haemozoin which prevents the detoxification of haem inside the parasitic digestive system and thereby kills the parasite. However, hydroxychloroquine is not effective against chloroquine-resistant strains of P.falciparum.

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