Can tamoxifen cause ovarian cysts

Discussion in 'Drug Costs' started by TpaBkuH, 26-Aug-2019.

  1. Fantegero Moderator

    Can tamoxifen cause ovarian cysts


    I was diagnosed with breast cancer in January when I was 50. Baseline tests revealed I had a small (2cm) ovarian cyst on each ovary- considered not a problem. When I was 20 I had 2 chocolate cysts the size of “small oranges” removed from my ovaries. I was put on 2 nine month durations of Provera to induce ‘pseudo-pregnancies’. For 4 hours the doctor removed microscopic bits of endometrial tissue, removed adhesions, and put my organs back into place. He followed that up with daily “tubal flushes” for a week to keep my fallopian tubes open. I knew I’d be better off keeping myself intact and looked for alternatives. Now I have the breast cancer diagnosis and I had a lumpectomy and radiation. I was perimenapausal at this point, but the Tamoxifen stopped what little spotting I had. I had a transvaginal ultrasound and it showed that my left cyst and increased from 2cm to 4.5 cm, but described as “simple”. After 2 miscarriages it was determined that I had an ‘inadequate luteal phase’. Ten years ago I started having very heavy periods, very frequently (10 days long every 21 days). I asked him about an endometrial ablation and he referred me to another specialist. I still had minor spotting at the time of my periods… My oncologist ordered a blood test and it showed my estradiol levels as high (386). In 1977 I got pregnant and was one of the first users of progesterone suppositories. I should mention that I had genetic testing and I came up negative for the BRCA1 and 2 genes. So this appears not to be cancer, but just a simple cyst that is causing me discomfort. The doctors would like to reduce my estrogen level because of the breast cancer. Adjuvant endocrine therapy is an integral component of care for endocrine‑dependent breast cancer. The aim of this type of therapy is to counteract the production and the action of estrogens. The ovary is the primary site of estrogen production in premenopausal women, whereas, in postmenopausal women, the main source of estrogens is adipose tissue. Therefore, ovarian function suppression is an effective adjuvant strategy in premenopausal estrogen‑dependent breast cancer. Similarly, the inhibition of estrogen action at the receptor site by tamoxifen has proven to be effective. To date, international consensus statements recommend tamoxifen (20 mg/day) for five years as the standard adjuvant endocrine therapy for premenopausal women. It should be noted that tamoxifen is a potent inducer of ovarian function and consequent hyperestrogenism in premenopausal women.

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    I was on tamoxifen for about 2 years, developed ovarian cysts and took a 6 month holiday to see whether the drug was the cause. I am quite sure it was, as the cysts disappeared. I am quite sure it was, as the cysts disappeared. I will be in hospital for 2/3 days apparently and then I am off work for 6-8. and the ovarian cyst still there, plus no sign of menopause yet at 54! About the side-effects of tamoxifen has focused mainly on the occurrence of. premenopausal women tamoxifen use can result in ovarian cysts and possibly.

    I was diagnosed as DCIS and had Mastectomy in Sept. So, after consulting with my Oncologists and Gyn (2 of them agreed for me to stop Tamoxifen and 2 others against it), I decided to stop Tamoxifen. I did some google-searches and discovered some important recent studies consistently finding that the pre-menopause women with breast cancer and ER (just like me) have 50-81% of chance to develop an ovarian cyst after taking Tamoxifen. Only about two weeks ago, I stopped Tamoxifen because I found a 7cm ovarian cyst through ultrasound. Based on your experiences, did you have similar problems in developing an ovarian cyst with Tamoxifen? Did the cyst go away by itself after you stop Tamoxifen? they hurt at times but understand unharmful and usually disolve on own. And did you have a single or double mastectomy and did you have clean margins (I assume you did since you don't mention radiation)? Moreover, if I take out the cyst by surgery and then start taking Tamoxifen again, will I see some new cysts pop up in the future? But my sister and her sister in law who were also on Tamoxifen, both did. I am going for quality of life for now and see if it reoccurs as I go along. i am scheduled fir my third d&c since starting tomox for uterine thickness and polyp removals. The consensus from the oncologists I have seen and the boards for DCIS on is that if ONLY DCIS with no micro-invasions or IDC involvment AND had a BMX, Tamoxifen is overtreatment. I very much appreciate it if you could share your experiences with me on what you went through on this and what advice you may provide to help me make a right decision. And they both had their ovaries removed and continued with Tamoxifen. As all these meds are now supposed to be taken for 10 years duration I just refuse to wait until nearly 70 to feel better, be ache free (by then normal aches will have come any way), and not look seven months pregnant. My mum took Tamoxifen for five years, then the norm, and got two different breast cancers after that. The head of the oncology clinic I saw said that since I had DCIS, with clean margins with a BMX, that since the milk ducts were gone, the cancer was gone (although we know that there is always a chance of reoccurrence even though it is extemely small, it can happen) and Tamoxifen would be overtreatment and the possible negative side effects would outweigh any benefits of that particular drug. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Tamoxifen treatment for breast cancer may induce ovarian cysts and supraphysiological levels of serum estrogen. We report successful management with luteinizing hormone-releasing hormone (LHRH) agonist of ovarian hyperstimulation induced by tamoxifen. A 49-year-old woman was operated on for invasive ductal carcinoma of the right breast. She received breast irradiation and adjuvant tamoxifen therapy. After 2 years, she had a cystic ovarian mass, and her serum concentration of estradiol was 1280 pg/m L. She was treated with an injection of 11.25 mg leuprolide acetate, a long-acting LHRH agonist, without abandoning tamoxifen therapy.

    Can tamoxifen cause ovarian cysts

    Ovarian hyperstimulation syndrome in a patient treated with., Ovarian cysts & tamoxifen - Breast Cancer Care Forum - 1197739

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  6. Dec 27, 2017. Tamoxifen treatment for breast cancer may induce ovarian cysts and. agonists can cause regression of the cysts and enable continuation of.

    • Long-Acting Luteinizing Hormone-Releasing Hormone Agonist for..
    • Ovarian cysts in women receiving tamoxifen for. - BioMedSearch.
    • Tamoxifen and ovarian cyst Cancer Survivors Network.

    Apr 10, 2011. Baseline tests revealed I had a small 2cm ovarian cyst on each ovary-. not to be cancer, but just a simple cyst that is causing me discomfort. If I have the cyst alone removed, will they most likely return in the Tamoxifen. Key Words Ovarian cyst - tamoxifen - breast cancer - ovarian cancer. endometrial cancer. Up to 1985, a low incidence of side effects was. noted in all reports on. the ovaries can either be the result of functional cysts in. Mar 12, 1999. Tamoxifen is a nonsteroidal anti-oestrogen with gynaecological side-effects. Only recently, ovarian cyst formation during tamoxifen treatment.

     
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