Additionally, another exception occurred while executing the custom error page for the first exception. This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Mylan hydroxychloroquine side effects Hydroxychloroquine side effects kidney Cytochrome P450 Drug Interactions Lead authors Terri L. Levien. and Danial E. Baker, Pharm. D. FASCP, FASHP Last Updated May 2003-See newly added CYP2C8 category on page 4 The characterization of drug interactions by metabolic pathways is complex. Just because a medication interacts with one Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Hydroxychloroquine is a prescription drug. It comes as an oral tablet. Hydroxychloroquine is available as the brand-name drug Plaquenil. It’s also available in a generic version. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. Hydroxychloroquine cyp Association of Polymorphisms of Cytochrome P450 2D6 With., Recommendations on Screening for Chloroquine and. Plaquenil and osteoarthritis B Cytochrome P450 CYP enzymes mediate dealkylation of chloroquine and hydroxychloroquine. Desethylchloroquine is an immediate downstream product of CYP-mediated dealkylation of both drugs. Mechanisms of action of hydroxychloroquine and chloroquine.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine Uses, Dosage & Side Effects -. Cytochrome P450 enzymes CYP 2D6, 2C8, 3A4 and 3A5 N-desethylated Hydroxychloroquine to Ndesethylhydroxychloroquine. Medical Use Hydroxychloroquine has been used for many years to treat malaria. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects. Drugs that inhibit CYP3A4 enzymes may increase plasma levels of hydroxychloroquine. Proton pump inhibitors may antagonize the immunomodulating effects of hydroxychloroquine. 7. Additional known interactions between hydroxychloroquine and coadministered drugs may be described in the FDA-approved Full Prescribing Information for Plaquenil. 9.