Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil 200 Abruptly stopping plaquenil Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. General feeling of tiredness or weakness headache inability to move the eyes increased blinking or spasms of the eyelid joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs loss of hearing lower back or side pain noisy breathing painful or difficult urination Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine and tiredness Hydroxychloroquine - Side Effects, Dosage, Interactions., Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Hydroxychloroquine gastrointestinal side effectsChloroquine autophagy hela Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Hydroxychloroquine MedlinePlus Drug Information. Long-Term Side Effects of Plaquenil for Rheumatoid.. Efficacy and Safety of Hydroxychloroquine for Treatment of.. Fatigue is often described as one of the most debilitating symptoms of Sjögren’s. I long for normal energy and the ability to sustain activity, any activity. I long for the kind of fatigue that gets better with a good night's sleep. I want to be able to do things spontaneously. But I'm really struggling with fatigue now - worse than its ever been. Don't know whether its the RA itself or my body reacting to Plaquenil but I can't seem to do anything without being really really tired. I wake up tired, I have a wash and it wipes me out, I have a nap and I'm tired and in the evening, I have zilch energy for anything. Hydroxychloroquine and the immune system. But do look after yourself, and make sure you eat well and don't get too tired as if you have a cold already you need to pamper yourself a bit more than you would have before RA. Polly. Hydroxychloroquine; Supporting the community See all. Eleanor-NRAS Administrator.