Also had to have an occupational health meeting today for my job as not worked for 6 months now and hoping they make me redundant as i can't work as a waitress with ra due to pain and flares in my opinion. (others may do) and i then can get benefits till i find a job i can do with the ra(i am not doing this just for benefits, i hope people understand that) I have now been on Plaq for just over three years and MTX for just under three years. Plaquenil while pregnant risks Sulfasalazine and plaquenil Is chloroquine-primaquine capitalized Lupus & methotrexate research. While lupus is not specifically approved for lupus, there have been a large number of studies that intend to measure the effectiveness of the drug for people with lupus. Some studies are quite specific, finding benefit of methotrexate for people with cutaneous lupus, antimalarial-resistant lupus arthritis, and. Dec 15, 2010 methotrexate and plaquenil. now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. i am still in so much pain everyday and hoping for some relieve soon. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. My Rheumy suggested MTX and told me it would be months before we knew for sure it would work. The combination works well for me-though I also take a NSAID. I started feeling better about a month after starting plaq-I was also on prednisone at the time-but couldn't get all the way well. Methotrexate and plaquenil for lupus Methotrexate in patients with moderate systemic lupus., Methotrexate and plaquenil - Hydroxychloroquine nutrient interactionsPlaquenil lyme disease treatmentPlaquenil side effects pregnancyMethotrexate hydroxychloroquinePlaquenil fatigue lupus Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Hydroxychloroquine Uses, Dosage & Side Effects -. Treating Lupus with Immunosuppressive Medications Johns.. Methotrexate In treating lupus, prednisone and the anti-malarial drugs such as Plaquenil remain the cornerstone of treatment because of their effectiveness and safety. Because of some of the side effects, some people do not respond well to prednisone and Plaquenil. I had a biopsy and my doctor said he believes it is morphea. I am waiting on my blood test to come back and he said as soon as it does he will put me on both methotrexate and plaquenil. The doctor is. Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and. View more. Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria, Malaria Prevention, Rheumatoid Arthritis, Systemic Lupus Erythematosus.