These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Plaquenil and methotrexate together Is plaquenil considered a blood thinner This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The side effect that is of greatest concern is retinal toxicity. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells but potentially serious eye toxicity can occur. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. If you notice any other effects, check with your healthcare professional. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. What r the side effects of plaquenil Plaquenil Withdrawal – Life As An Anomaly, Hydroxychloroquine Plaquenil Side Effects & Dosage for. Is hydroxychloroquine sulfate safeChloroquine proguanil side effectsPlaquenil use during pregnancyInstructions for taking chloroquinePlaquenil lower plateltls Serious Side Effects of Plaquenil. If you are taking Plaquenil long-term, such as for an autoimmune condition, your doctor should regularly check you for potential serious side effects. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Common and Rare Side Effects for Plaquenil Oral. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects. Hello people! I have a questions for you regarding Plaquenil experiences. I know you guys aren't doctors and what not, but it would be nice to hear if this is normal because this is affecting me a lot. I started on it last month and have been having nothing but side effects. Package inserts for hydroxychloroquine Plaquenil report side effects that may be seen in patients taking hydroxychloroquine at recommended doses for rheumatoid arthritis RA or systemic lupus erythematosus. 1,2 In available studies, the frequency of reported side effects has been low, and are usually mild. 3 Many side effects are transient.