I took plaquenil for a while and it helped to reduce the duration/severity of the flairs, but I still had them. Both these drugs can take up to 3 months to begin to work. Plaqenil didn't stop my flare ups, but did ease some of the symptoms. It might also be worth checking what brand you have, as there are many posts on here about adverse reaction to a cheaper brand. Plaquenil for pmle Plaquenil excretion Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset. Does Plaquenil Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in. I am on 200mg of plaquenil & 50mg of Imuran daily, been on both for over a month. How long does it take to kick in before you really start feeling better? Would my dosage be too low to see results. renalupie1 responded It could take several months to feel a difference. If in about 6 to 8 weeks you aren't seeing the slightest change, or don't. So it's worth taking some time to think about other possible causes. XBeen taking plaquenil for some 13 years now - seems to reduce the flairs but doesn't stop them. There are many possible triggers for a flare, & as lupus sufferers we are all different. Imuran plaquenil together PATIENT FACT SHEET Hydroxychloroquine Plaquenil, Plaquenil Oral Interactions with Other Medication Hydroxychloroquine sul 200Malaria hydroxychloroquine resistance SIDE EFFECTS. The principal and potentially serious toxic effects of IMURAN are hematologic and risks of secondary infection and malignancy are also significant see WARNINGSfrequency and severity of adverse reactions depend on the dose and duration of IMURAN as well as on the patient's underlying disease or concomitant therapies. Side Effects of Imuran Azathioprine, Warnings, Uses. Plaquenil & Imuran" Lupus Community - Support Group. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. I have been taking plaquenil for almost 27 years and have never had any eye issues. For the first 20 years I did visual fields every 6 months but my opthamologist has reduced it to once a year since I have never had any issues. Plaquenil is the first line of defense for ctreating lupus and has worked incredibly well for me! Lupylisa Interaction between Imuran and Plaquenil There is no known interaction between Imuran and Plaquenil in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice. It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. Azathioprine is insoluble in water, but may be dissolved with addition of one molar equivalent of alkali. Azathioprine is stable in solution at neutral or acid pH but hydrolysis to mercaptopurine occurs in excess sodium hydroxide 0.1N, especially on warming.