While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I started the hydroxychloroquine medication a week ago and within the first day or two noticed a big difference in my pain and fatigue with major improvement SLE. Calcium autophagy chloroquine Plaquenil and low libido Drug metabolism of plaquenil Hydroxychloroquine used for diabetes Oct 23, 2005 I have been on Placquenil for quite a few years for systemic lupus. I have never heard of anyone taking it for CFS. I don't know how it could help with your energy level, because it certainly never has with mine. In fact, my fatigue is getting worse, almost unbearable. Jul 16, 2018 Plaquenil and Depression/Anxiety. I was diagnosed with Sjogren’s a year ago Early Sjogren’s Panel by the doctor I see for Ehlers-Danlos Syndrome. I started at a very low dose- 100mg per day 1/2 of a 200 mg tablet, in addition to a small dose of modafinil I was taking for fatigue, which is my worst symptom. I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. While there is good clinical evidence demonstrating the drug’s efficacy in rheumatoid arthritis and lupus, there are very few studies looking at hydroxychloroquine as a treatment for Sjögren’s. Plaquenil (hydroxychloroquine) is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Can plaquenil help with fatigue Want to know good stuff about plaquenil - HealthBoards, Plaquenil and Depression/Anxiety - Symptoms and Medical. Psoriasis and plaquenilTab chloroquine dose For me, plaquenil is the only thing that has ever got rid of the fatigue. However, I would not rule it out as a side effect we all react differently. Is extreme fatigue a side effect of Plaquenil?. Plaquenil for fatigue and pain DailyStrength. Plaquenil and Fibromyalgia. Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. Fatigue is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated regularly. What is the best medication to treat Lupus fatigue. Every time I ask my doctors or search online, all I can get are statements regarding cognitive therapy, sleep deprivation, diet, exercise, or depression. Nothing at all useful regarding medications available that help increase energy. Has anyone found anything that works? Thank you so much!