Chloroquine resistance definition

Discussion in 'Online Canadian Pharmacy' started by seomanik, 17-Mar-2020.

  1. Chloroquine resistance definition


    Rapid diagnostic assays for Pf CRT mutations are already employed as surveillance tools for drug resistance. Here, we review recent field studies that support the central role of Pf CRT mutations in chloroquine resistance.

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    Development of Chloroquine Resistance in Plasmodium falciparum. Drug resistance is the ability of a parasite to survive despite the presence of a drug that is meant to kill it in toxic levels. Resistance developed by most parasites that were initially sensitive to drugs mostly result from mutations in the genes responsive to the drug. Chloroquine resistance discuss below in more detail has been correlated with mutations in a transporter found on the food vacuole membrane chloroquine resistance transporter, CRT. Another food vacuole transporter, multi-drug resistance gene 1 MDR1, has been implied to play an ancillary role in resistance. P. falciparum or Species Not Identified – Acquired in Areas Without Chloroquine Resistance. For P. falciparum infections acquired in areas without chloroquine-resistant strains, which include Central America west of the Panama Canal, Haiti, and the Dominican Republic, patients can be treated with oral chloroquine.

    Recognition of the value of chloroquine was delayed, and it was not brought forward until it was reevaluated in the United States and designated the drug of choice against malaria near the end of World War II [3]. These studies suggest chloroquine resistance arose in ⩾4 distinct geographic foci and substantiate an important role of immunity in the outcomes of resistant infections after chloroquine treatment. Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency Early in the 20th century, intense demands for an effective quinine substitute launched the discovery and evaluation of a series of organic compounds (beginning with methylene blue), which led to pamaquine and quinacrine after World War I and ultimately produced chloroquine in 1934 [1, 2].

    Chloroquine resistance definition

    Chloroquine definition of chloroquine by Medical dictionary, Mechanisms of drug action and resistance

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  7. Chloroquine definition is - an antimalarial drug C18H26ClN3 administered in the form of its bitter crystalline diphosphate.

    • Chloroquine Definition of Chloroquine by Merriam-Webster.
    • CDC - Malaria - Diagnosis & Treatment United States..
    • An ortholog of P. falciparum chloroquine resistance..

    Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. P. falciparum has developed resistance to nearly all antimalarial drugs currently in use; P. vivax has been found to be resistant to chloroquine and primaquine; and P. Malariae has been reported to be resistant to chloroquine and pyrimethamine in some areas.1-3

     
  8. Ruslan555 Well-Known Member

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  9. Stratoboy Guest

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as.

    Plaquenil - Concordia Pharmaceuticals Inc.