Estrace is made use of for dealing with problems because of menopause (eg, warm flashes; genital itchiness, burning, or dry skin), dealing with vulval or vaginal atrophy, and also stopping osteoporosis (breakable bones). It is additionally made use of for estrogen replacement therapy after failing of the ovaries and to soothe the signs of breast cancer. Estrace is utilized for dealing with sophisticated prostate cancer. Usage Estrace as routed by your medical professional. If indigestion takes place, take with food to decrease belly irritability. Grapefruit and also grapefruit juice might raise the threat of Estrace's negative effects. Speak to your medical professional before including grapefruit or grapefruit juice in your diet plan while you are taking Estrace. If you miss out on a dosage of Estrace, take it as quickly as possible. Estrace is a form of estrogen, which is a naturally produced female sex hormone secreted by the ovaries. 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