Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine suicide survivor How to bill for following plaquenil retina icd-10 Summary. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. According to the Mayo Clinic and New Zealand Dermatological Society, Plaquenil, given long term for diseases such as RA, can cause brain and nerve diseases such as headaches, dizziness, muscle weakness and seizures. Then rest in a darkened room. Remember also to keep hydrated.being slightly dehydrated can trigger headaches and migraines. I still take Plaquenil and have been on them since 2006. The migraines are no better or worse than before. So in my experience, the Plaquenil is not a problem for me. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause headaches The Risk of Retinal Toxicity with Plaquenil, Long-Term Side Effects of Plaquenil for Rheumatoid. Keyhole chloroquine Feeling that others can hear your thoughts feeling, seeing, or hearing things that are not there fever with or without chills general feeling of tiredness or weakness headache inability to move the eyes increased blinking or spasms of the eyelid joint or muscle pain Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Migraines and plaquenil. Connection? DailyStrength. Plaquenil and weight gain -. I take plaquenil for RA, MCTD, etc. it worsens headache that are daily 24/7. Most drugs I took for AI diseases, prescribed by my rheumy, worsened headaches. The headaches range from mild to migraine, to dizzying. My neurologist is now evaluating me for a cerebral spinal fluid leak which can cause positional headache. Thanks for your advice, Shani. The headaches were just bad headaches and stopped when I started taking Plaquenil at night instead of the morning. The blurred vision came separately and went a day or two after I stopped the Plaquenil again. As it happens, my GP phoned me today about something else and I told her about this. When I started Plaquenil back in November last year, I had terrible headaches which started about 1/2 an hour after taking pills. It happened so consistently that I started taking tylenol when I would take it. I would lay down with an ice pack under my neck and darken the room. After about 30min of resting with the ice pack.