Effect of chloroquine on liver enzymes

Discussion in 'Reliable Pharmacy' started by Boris Baydenko, 24-Feb-2020.

  1. alex1977 User

    Effect of chloroquine on liver enzymes


    Swiss albino mice were administered with different amounts of CQ ranging from human therapeutic equivalent of 360 mg/kg body wt. We observed statistically significant generation of reactive oxygen species, liver toxicity, and oxidative stress. Our observation of alterations in biochemical parameters was strongly supported by real-time PCR measurement of m RNA expression of key biochemical enzymes involved in hepatic toxicity and oxidative stress.

    Hydroxychloroquine and corticosteroids Plaquenil and heart issues

    Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver. Following administration chloroquine is rapidly dealkylated via cytochrome P450 enzymes CYP into the pharmacologically active desethylchloroquine and bisdesethylchloroquine. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. In the case of 100 mg kg −1 day −1 the effect was highly significant compared with the other doses 10 and 30 mg kg −1 day −1. The results of the study revealed that α‐lipoic acid could offer protection against chloroquine‐induced hepatotoxicity. α‐Lipoic acid had a better protective effect when compared with silymarin, a.

    We further tested quercetin, an antioxidant flavanoid, against CQ-induced hepatoxicity and found encouraging results as quercetin was able to drastically reduce the oxidative stress and hepatotoxicity resulting at higher dosages of CQ administration. However, the observed hepatotoxicity and accompanying oxidative stress following CQ administration show dose specific pattern with little or apparently no effect at therapeutic dose while having severe effects at higher dosages.

    Effect of chloroquine on liver enzymes

    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs, Chloroquine - Wikipedia

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  6. Plaquenil has never raised my liver enzymes and I have been on it for six years. The only time my ALT and AST were elevated when I was taking too much iron supplements for my anemia. Once I stopped those, the enzymes went back to normal.

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    Jan 13, 1987 Chronic chloroquine treatment of miniature pigs resulted in increased activity of several lysosomal enzymes of the liver and brain. The most affected enzyme was alpha-fucosidase which showed a 3-fold increase in liver P less than 0.001 and a 2-fold increase in the brain P less than 0.01. Our Plaquenil hydroxychloroquine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Oct 01, 2018 Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

     
  7. ayda Guest

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION Covis Pharma S.a.r.l. - Company Profile - BCIQ
     
  8. Fernflier Moderator

    Description: An exception occurred while processing your request. Hydroxychloroquine Side Effects, Dosage, Uses, and More Mechanisms of action of hydroxychloroquine and chloroquine. Hydroxychloroquine and Chloroquine Retinopathy 9781493905966 Medicine.
     
  9. Listopad_2 Guest

    Aralen Chloroquine MyLupusTeam Aralen is also known by its drug name, Chloroquine. Aralen may not be appropriate for people with certain vision conditions or known hypersensitivity to related drugs. Aralen should be used with caution by people who have auditory damage, liver disease, alcoholism, or a history of epilepsy.

    CHLOROQUINE PHOSPHATE, USP
     
  10. Verbatem XenForo Moderator

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    Let me tell you what weaning down from Plaquenil is like.