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Do not take your medicine more often than directed. You must gradually reduce the dose or you may get a dangerous increase in blood pressure. read more They need to know if you have any of these conditions: -kidney disease -an unusual or allergic reaction to clonidine, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding Take this medicine by mouth with a glass of water. Ask your doctor or health care professional for advice. Do not take this medicine with any of the following medications: -MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate This medicine may also interact with the following medications: -barbiturate medicines for inducing sleep or treating seizures like phenobarbital -certain medicines for blood pressure, heart disease, irregular heart beat -certain medicines for depression, anxiety, or psychotic disturbances -prescription pain medicines This list may not describe all possible interactions. 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