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Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. where to buy retin a for acne Patients with hepatic impairment Efracea should be administered with caution to patients with hepatic impairment or to those receiving potentially hepatotoxic medicinal products (see section 4.4) Paediatric population Efracea is contraindicated in children below 12 years of age (see section 4.3). Patients with renal impairment No dosage adjustment is necessary in patients with renal impairment. The capsule should be taken in the morning, on an empty stomach, preferably at least one hour prior to or two hours after the meal. The capsule should be taken with adequate amounts of water in order to reduce the risk of oesophageal irritation and ulceration (see section 4.4). Patients should be evaluated after 6 weeks and, if no effect is seen, consideration should be given to stopping treatment. 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