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  1. Viagra classification


    Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, c GMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased c GMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH. where can i buy viagra over the counter in london However, patient may take drug 30 minutes to 4 hours before sexual activity. as a single dose, p.r.n., 1 hour before sexual activity. Based on effectiveness and tolerance by patient, may increase dose to maximum single dose of 100 mg or decrease dose to 25 mg. A maximum recommended dosing frequency is once daily. Erectile action: Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cyclic guanosine monophosphate (c GMP) in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of c GMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Absorption: Rapidly absorbed after oral administration. A high-fat meal delays the rate of absorption by about 1 hour and reduces peak levels by one-third.

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    Sildenafil citrate. Viagra. Pharmacologic classification selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5. Therapeutic. levitra tab VIAGRA 25 mg tablets are blue film-coated, rounded diamond-shaped tablets, marked. In volunteers with hepatic cirrhosis Child-Pugh classification A and B. The change concerned 'switching' the classification of the medicine from ' medicinal product subject to medical. What was Viagra expected to be used for ?

    Viagra is the trade name of sildenafil, an anti-impotence drug, belonging to a new group of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. Developed originally as a treatment for angina, patients prescribed with Viagra reported erections as an unexpected side effect. As an inhibitor, the drug works by improving the blood flow to the penis by stopping the degradation of cyclic guanosine monophosphate (c GMP) – a chemical released during sexual stimulation which relaxes the smooth muscle in the penis. Once these muscles have been relaxed, blood vessels are able to dilate, allowing the blood flow to the penis to increase. By selectively inhibiting the breakdown of c GMP, Viagra uniquely promotes the flow of blood into the penis at times of sexual stimulation, therefore facilitating an erection, though not causing one. Viagra therefore does not increase sexual desire (although a side effect may be an increase in confidence which in turn may increase sexual desire). It follows also that those who do not suffer from impotence caused by insufficient blood flow may gain little from taking the drug. The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart.

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  5. Dec 7, 2018. Revatio, Viagra. Prescribed For. Pulmonary arterial hypertension PAH. Erectile dysfunction ED. Drug Classification. Phosphodiesterase-5.

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    Viagra is the trade name of sildenafil, an anti-impotence drug, belonging to a new group of drugs known as phosphodiesterase type 5 PDE5 inhibitors. when to draw keppra levels Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension PAH. Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its. Drug Classification. VIAGRA prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects.

     
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