Acyclovir’s benefit lies in it ability to treat two common viral infections: varicella-zoster (the cause of chickenpox and shingles) and herpes simplex (cold sores and genital herpes). It works by preventing viruses from dividing and multiplying. It is available over the counter as a treatment for cold sores on the lips and surrounding area. Apply acyclovir ointment to the affected area every three hours. However, first check the correct dosage with your Clicks pharmacist. To avoid adverse drug interactions, always inform your doctor or Clicks pharmacist what prescription and non-prescription medications, vitamins, nutritional supplements and herbal products you are taking or planning to take. Side effects could include: This is not a complete list of side effects. diflucan used to treat Zovirax cream can be prescribed to treat cold sores and genital herpes, which are both caused by infection with the herpes simplex virus (HSV). 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